| dog |
LD50 |
intravenous |
6250ug/kg (6.25mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Cancer Treatment Reports. Vol. 64, Pg. 855, 1980. |
| dog |
LD50 |
oral |
50mg/kg (50mg/kg) |
BEHAVIORAL: FOOD INTAKE (ANIMAL)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
Cancer Treatment Reports. Vol. 66, Pg. 1939, 1982. |
| human |
TDLo |
intravenous |
12mg/kg (12mg/kg) |
VASCULAR: THROMBOSIS DISTANT FROM INJECTION SITE
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: OTHER CHANGES |
Cancer Research. Vol. 38, Pg. 3712, 1978. |
| man |
LDLo |
intravenous |
5405ug/kg/3H- (5.405mg/kg) |
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Archives of Internal Medicine. Vol. 143, Pg. 165, 1983. |
| monkey |
LDLo |
intravenous |
10400ug/kg (10.4mg/kg) |
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Pharmacy International. Vol. 7, Pg. 3, 1986. |
| mouse |
LD50 |
intraperitoneal |
15470ug/kg (15.47mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
intravenous |
33700ug/kg (33.7mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Cancer Treatment Reports. Vol. 64, Pg. 855, 1980. |
| mouse |
LD50 |
oral |
53420ug/kg (53.42mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
subcutaneous |
110mg/kg (110mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
