51333-22-3|S-budesonideProducts Supply - Chemical intermediates Network

S-budesonide cas no:51333-22-3

Synonyms: Budesonide

Identification

NameS-budesonide
CAS51333-22-3
SynonymsBudesonide
EINECS(EC#)257-139-7
Molecular FormulaC25H34O6
Molecular Weight430.54

Chemical Properties

Appearancewhite solid
refractive index1.592
storage tempStore at RT

Safety Data

Hazard Xn:Harmful
Risk R40
Safety

Hazard Codes:? Harmful Xn
Risk Statements: 40-36/37/38-20/21/22?
R40: Limited evidence of a carcinogenic effect.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36-26?
S22: Do not breathe dust.?
S36: Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: TU3723000
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and fumes.

HS Code 29372900

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	subcutaneous	173mg/kg (173mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
man	TCLo	inhalation	34ug/kg (0.034mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Australian and New Zealand Journal of Medicine. Vol. 22, Pg. 511, 1992.
mouse	LD50	intraperitoneal	179mg/kg (179mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse	LD50	intravenous	124mg/kg (124mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse	LD50	oral	4750mg/kg (4750mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
mouse	LD50	subcutaneous	53600ug/kg (53.6mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat	LD50	intraperitoneal	138mg/kg (138mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat	LD50	intravenous	98900ug/kg (98.9mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat	LD50	oral	> 3200mg/kg (3200mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.
rat	LD50	subcutaneous	58400ug/kg (58.4mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BLOOD: CHANGES IN SPLEEN	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 4377, 1985.

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S-budesonide cas no:51333-22-3

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