child |
TDLo |
intravenous |
100mg/kg (100mg/kg) |
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP |
Annals of Internal Medicine. Vol. 97, Pg. 283, 1982. |
dog |
LD50 |
intravenous |
206mg/kg (206mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
GASTROINTESTINAL: OTHER CHANGES |
Kiso to Rinsho. Clinical Report. Vol. 14, Pg. 2806, 1980. |
dog |
LD50 |
oral |
2600mg/kg (2600mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 329, 1977. |
hamster |
LD50 |
intraperitoneal |
880mg/kg (880mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Gastroenterology. Vol. 74, Pg. 339, 1978. |
hamster |
LD50 |
oral |
4gm/kg (4000mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Gastroenterology. Vol. 74, Pg. 339, 1978. |
human |
TDLo |
oral |
80mg/kg/8D (80mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
BLOOD: LEUKOPENIA |
Lancet. Vol. 1, Pg. 444, 1978. |
man |
TDLo |
intravenous |
4286ug/kg/30M (4.286mg/kg) |
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER |
Annals of Internal Medicine. Vol. 97, Pg. 374, 1982. |
man |
TDLo |
oral |
2857ug/kg (2.857mg/kg) |
CARDIAC: OTHER CHANGES |
Lancet. Vol. 1, Pg. 225, 1987. |
man |
TDLo |
oral |
51mg/kg/3D-I (51mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
American Journal of Medicine. Vol. 75, Pg. 875, 1983. |
man |
TDLo |
oral |
57mg/kg/5D-I (57mg/kg) |
LIVER: "JAUNDICE, CHOLESTATIC" |
Digestive Diseases and Sciences. Vol. 32, Pg. 333, 1987. |
man |
TDLo |
oral |
270mg/kg/3W-I (270mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS |
American Journal of Medicine. Vol. 70, Pg. 1272, 1981. |
man |
TDLo |
unreported |
600mg/kg/6W (600mg/kg) |
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Lancet. Vol. 1, Pg. 1160, 1981. |
mouse |
LD50 |
intraperitoneal |
306mg/kg (306mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1655, 1983. |
mouse |
LD50 |
intravenous |
150mg/kg (150mg/kg) |
? |
Journal of International Medical Research. Vol. 3, Pg. 86, 1975. |
mouse |
LD50 |
oral |
2550mg/kg (2550mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
mouse |
LD50 |
subcutaneous |
437mg/kg (437mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
rabbit |
LD50 |
intraperitoneal |
1063mg/kg (1063mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
rabbit |
LD50 |
intravenous |
164mg/kg (164mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
rabbit |
LD50 |
oral |
> 8640mg/kg (8640mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
rat |
LD50 |
intraperitoneal |
328mg/kg (328mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
rat |
LD50 |
intravenous |
106mg/kg (106mg/kg) |
? |
Journal of International Medical Research. Vol. 3, Pg. 86, 1975. |
rat |
LD50 |
oral |
5gm/kg (5000mg/kg) |
? |
Journal of International Medical Research. Vol. 3, Pg. 86, 1975. |
rat |
LD50 |
subcutaneous |
860mg/kg (860mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 11, Pg. 1685, 1983. |
women |
LDLo |
intravenous |
1008mg/kg/6W- (1008mg/kg) |
VASCULAR: OTHER CHANGES |
Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 126, 1983. |
women |
TDLo |
intravenous |
4mg/kg/2M-C (4mg/kg) |
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP |
Lancet. Vol. 1, Pg. 99, 1987. |
women |
TDLo |
oral |
30mg/kg/2D-I (30mg/kg) |
BEHAVIORAL: ATAXIA
BEHAVIORAL: REGIDITY
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) |
Annals of Emergency Medicine. Vol. 16, Pg. 1162, 1987. |