4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,hydrochloride (1:1), (aS)-rel- cas no:51773-92-3
Synonyms: 4-Quinolinemethanol,a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel- (9CI);4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (R*,S*)-(?à)-;4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-;Loriam;Mefloquin hydrochloride;NSC 157387;Ro21-5998/001;
Name4-Quinolinemethanol, a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,hydrochloride (1:1), (aS)-rel-
CAS51773-92-3
Synonyms4-Quinolinemethanol,a-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (aS)-rel- (9CI);4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-,monohydrochloride, (R*,S*)-(?à)-;4-Quinolinemethanol, a-2-piperidinyl-2,8-bis(trifluoromethyl)-, monohydrochloride, (R*,S*)-;Loriam;Mefloquin hydrochloride;NSC 157387;Ro21-5998/001;
EINECS(EC#)257-412-0
Molecular FormulaC17H16F6N2O.HCl
Molecular Weight414.77
AppearanceOff-white to yellow solid.
storage tempStore only in the original container. Keep container tightly sealed.
Hazard Xn: Harmful;
Risk R22
Safety
Hazard Codes of Mefloquine hydrochloride (CAS NO.51773-92-3): 
Xn
Risk Statements: 22
R22: Harmful if swallowed.
WGK Germany: 3
RTECS: VC0308000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
TDLo |
oral |
11mg/kg/2W-I (11mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Annals of Internal Medicine. Vol. 114, Pg. 994, 1991. |
| man |
TDLo |
oral |
18mg/kg/5W-I (18mg/kg) |
PERIPHERAL NERVE AND SENSATION: PARESTHESIS
BEHAVIORAL: GENERAL ANESTHETIC |
Annals of Internal Medicine. Vol. 117, Pg. 1058, 1992. |
| man |
TDLo |
oral |
96mg/kg/52D-I (96mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: AGGRESSION |
Archives of Internal Medicine. Vol. 154, Pg. 2360, 1994. |
| rat |
LD50 |
intraperitoneal |
130mg/kg (130mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Acta Tropica. Vol. 37, Pg. 232, 1980. |
| rat |
LD50 |
oral |
880mg/kg (880mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Acta Tropica. Vol. 37, Pg. 232, 1980. |
| women |
TDLo |
oral |
15mg/kg/3W-I (15mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA |
Medical Journal of Australia. Vol. 161, Pg. 453, 1994. |
