16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,(4aS,16aS)- cas no:518-34-3
Synonyms: Berbaman,6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1b)-;Tetrandrine (6CI,7CI,8CI);(+)-Tetrandrine;(S,S)-Tetrandrine;16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,[4aS-(4aR*,16aR*)]-;Fanchinine;Hanfangchin A;NSC 77037;S,S-(+)-Tetrandrine;Sinomenine A;TTD;Tetrandrin;Tetrandrine;
Name16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,(4aS,16aS)-
CAS518-34-3
SynonymsBerbaman,6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1b)-;Tetrandrine (6CI,7CI,8CI);(+)-Tetrandrine;(S,S)-Tetrandrine;16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-,[4aS-(4aR*,16aR*)]-;Fanchinine;Hanfangchin A;NSC 77037;S,S-(+)-Tetrandrine;Sinomenine A;TTD;Tetrandrin;Tetrandrine;
Molecular FormulaC38H42N2O6
Molecular Weight622.75
AppearanceWhite solid.
alpha285 o (C=1, CHCL3)
refractive index1.585
storage temp:Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20 C.
Hazard Xi
Risk R36/37/38
Safety Poison by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XE9350000
- CHEMICAL NAME :
- Tetrandrine
- CAS REGISTRY NUMBER :
- 518-34-3
- BEILSTEIN REFERENCE NO. :
- 0877811
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C38-H42-N2-O6
- MOLECULAR WEIGHT :
- 622.82
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41300 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Cardiac - other changes
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- Sister chromatid exchange
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 80 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,5,1989
