1H-Purine-2,6-dione,3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl- cas no:519-37-9
Synonyms: Theophylline,7-(2-hydroxyethyl)- (7CI,8CI);7-(2-Hydroxyethyl)-1,3-dimethylxanthine;7-(2-Hydroxyethyl)theophylline;7-(Hydroxyethyl)theophylline;7-(b-Hydroxyethyl)theophylline;7-Theophyllineethanol;Aethophyllinum;Ascorphylline;Bio-phylline;Cordalin;Corophyllin-N;Dilaphyllin;Etofylline;Etophyllin;Etophylline;Frekaphyllin;Hydroxyethyltheophylline;KT 200G;NSC 113373;Oxphylline;Oxyethophylline;Oxyethyltheophylline;Oxyphyllin;Oxyphylline;Oxytheonyl;Phyllocormin N;Soluphylline;
Name1H-Purine-2,6-dione,3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-
CAS519-37-9
SynonymsTheophylline,7-(2-hydroxyethyl)- (7CI,8CI);7-(2-Hydroxyethyl)-1,3-dimethylxanthine;7-(2-Hydroxyethyl)theophylline;7-(Hydroxyethyl)theophylline;7-(b-Hydroxyethyl)theophylline;7-Theophyllineethanol;Aethophyllinum;Ascorphylline;Bio-phylline;Cordalin;Corophyllin-N;Dilaphyllin;Etofylline;Etophyllin;Etophylline;Frekaphyllin;Hydroxyethyltheophylline;KT 200G;NSC 113373;Oxphylline;Oxyethophylline;Oxyethyltheophylline;Oxyphyllin;Oxyphylline;Oxytheonyl;Phyllocormin N;Soluphylline;
EINECS(EC#)208-269-8
Molecular FormulaC9H12N4O3
Molecular Weight224.25
refractive index1.683
storage tempRefrigerator
Hazard Xn,Xi
Risk R22
Safety
Poison by ingestion, subcutaneous, intravenous and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. See also THEOPHYLLINE.
Hazard Codes:
Xn: Harmful
Xi: Irritant
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements:
S36: Wear suitable protective clothing.
S36/37: Wear suitable protective clothing and gloves.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: XH5850000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
400mg/kg (400mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 190, 1958. |
| mouse |
LD50 |
intravenous |
344mg/kg (344mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. |
| mouse |
LD50 |
oral |
400mg/kg (400mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1173, 1977. |
| mouse |
LD50 |
subcutaneous |
400mg/kg (400mg/kg) |
Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation skin and appendages (skin): sweating: other
|
Arzneimittel-Forschung. Drug Research. Vol. 4, Pg. 649, 1954. |
| rat |
LD50 |
intravenous |
486mg/kg (486mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. |
| rat |
LD50 |
oral |
710mg/kg (710mg/kg) |
Liver: other changes
|
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 2023, 1980. |
| rat |
LD50 |
subcutaneous |
176mg/kg (176mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957. |
