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2,4(1H,3H)-Pyrimidinedione,5-[bis(2-chloroethyl)amino]-6-methyl- cas no:520-09-2

Synonyms: Uracil,5-[bis(2-chloroethyl)amino]-6-methyl- (7CI,8CI);2,6-Dihydroxy-4-methyl-5-[bis(2-chloroethyl)amino]pyrimidine; 4-Methyl-5-[bis(b-chloroethyl)amino]uracil;Chloroethylaminouracil; Dopan; ENT 50698; Elderfield pyrimidine mustard; NSC44629

Identification
Name2,4(1H,3H)-Pyrimidinedione,5-[bis(2-chloroethyl)amino]-6-methyl-
CAS520-09-2
SynonymsUracil,5-[bis(2-chloroethyl)amino]-6-methyl- (7CI,8CI);2,6-Dihydroxy-4-methyl-5-[bis(2-chloroethyl)amino]pyrimidine; 4-Methyl-5-[bis(b-chloroethyl)amino]uracil;Chloroethylaminouracil; Dopan; ENT 50698; Elderfield pyrimidine mustard; NSC44629
Molecular FormulaC9H13 Cl2 N3 O2
Molecular Weight266.15
Chemical Properties
refractive index1.564
Safety Data

Safety

Poison by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of Cl and NOx.


Toxicity
1.    

cyt-hmn:leu 2500 µg/L

    TSITAQ    Tsitologiya. Cytology. 15 (1973),1505.
2.    

dni-mus:ast 2 mg/L

    NEOLA4    Neoplasma. 22 (1975),105.
3.    

oms-mus:ast 2 mg/L

    NEOLA4    Neoplasma. 22 (1975),105.
4.    

cyt-mky:kdy 100 mg/L

    TSITAQ    Tsitologiya. Cytology. 15 (1973),1505.
5.    

orl-rat LD50:2400 µg/kg

    BCFAAI    Bollettino Chimico Farmaceutico. 101 (1962),630.
6.    

ipr-mus LDLo:3 mg/kg

    FATOAO    Farmakologiya i Toksikologiya (Moscow). 34 (1971),83.

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