Androstan-3-one,17-hydroxy-17-methyl-, (5a,17b)- cas no:521-11-9

NameAndrostan-3-one,17-hydroxy-17-methyl-, (5a,17b)-
CAS521-11-9
Synonyms5a-Androstan-3-one, 17b-hydroxy-17-methyl-(6CI,7CI,8CI);17a-Methyl-17b-hydroxy-5a-androstan-3-one;17a-Methyl-5a-androstan-17b-ol-3-one;17a-Methyl-5a-dihydrotestosterone;17a-Methylandrostan-17b-ol-3-one;17a-Methylandrostan-3-on-17b-ol;17a-Methylandrostanolone;17a-Methyldihydrotestosterone;17b-Hydroxy-17-methyl-5a-androstan-3-one;17b-Hydroxy-17a-methyl-3-androstanone;17b-Hydroxy-17a-methyl-5a-androstan-3-one;5a-Androstan-17a-methyl-17b-ol-3-one;Androstalone;Assimil;Mestalone;Mestanolon;Mestanolone;Methybol;Methylandrostanolone;Methylantalon;NSC 18219;Preroide;RU 143;Tantarone;
EINECS(EC#)208-302-6
Molecular FormulaC20H32O2
Molecular Weight304.47

Appearancewhite to off-white crystalline powder
refractive index1.528
storage tempControlled Substance, -20?C Freezer

Hazard Xn
Risk R40
Safety Hazard Codes:Xn
Risk Statements:40
40:Limited evidence of a carcinogenic effect
Safety Statements:22-36
22:Do not breathe dust
36:Wear suitable protective clothing
WGK Germany:3

CHEMICAL IDENTIFICATION

RTECS NUMBER :

BV8064500

CHEMICAL NAME :

5-alpha-Androstan-3-one, 17-beta-hydroxy-17-methyl-

CAS REGISTRY NUMBER :

521-11-9

BEILSTEIN REFERENCE NO. :

3207223

LAST UPDATED :

199612

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C20-H32-O2

MOLECULAR WEIGHT :

304.52

WISWESSER LINE NOTATION :

L E5 B666 OVTJ A1 E1 FQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1240 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,817,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

160 mg/kg

SEX/DURATION :

female 14-21 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 94,979,1974