Trimipramine maleate cas no:521-78-8

NameTrimipramine maleate
CAS521-78-8
Synonymstrimipraminehydrogenmaleate
EINECS(EC#)208-318-3
Molecular FormulaC₂₀H₂₆N₂ . C₄H₄O₄
Molecular Weight410.56

storage temp2-8°C

Hazardclass6.1(b)

Hazard Xn,T,F
Risk 22-36/37/38-63-36/38-23/25
Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes Xn,T,F
Risk Statements 22-36/37/38-63-23/25
R22:Harmful if swallowed. 
R23/25:Toxic by inhalation and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin. 
R63:Possible risk of harm to the unborn child.
Safety Statements 26-36-45-33-24-16-7
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S33:Take precautionary measures against static discharges. 
S24:Avoid contact with skin. 
S16:Keep away from sources of ignition. 
S7:Keep container tightly closed.
RIDADR 3249
WGK Germany 3
RTECS HN9260000
HazardClass 6.1(b)
PackingGroup III

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	223mg/kg (223mg/kg)		Drugs in Japan Vol. -, Pg. 876, 1995.
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse	LD50	intravenous	40mg/kg (40mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse	LD50	oral	425mg/kg (425mg/kg)		Drugs in Japan Vol. 6, Pg. 526, 1982.
mouse	LD50	subcutaneous	240mg/kg (240mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit	LD50	intravenous	27mg/kg (27mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	British Journal of Pharmacology and Chemotherapy. Vol. 25, Pg. 158, 1965.
rat	LD50	intraperitoneal	150mg/kg (150mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	intravenous	38mg/kg (38mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	oral	800mg/kg (800mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat	LD50	subcutaneous	308mg/kg (308mg/kg)		Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970