522-48-5|1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1)Products Supply

1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1) cas no:522-48-5

Synonyms: 1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (9CI);2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride;Murine Plus;Soothe;Tinarhinin;Tizine;Tyzanol;Tyzanol hydrochloride;Tyzine;Tyzine hydrochloride;Visine;Visine hydrochloride;Vislin;Yxin;

Identification

Name1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1)
CAS522-48-5
Synonyms1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (9CI);2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride;Murine Plus;Soothe;Tinarhinin;Tizine;Tyzanol;Tyzanol hydrochloride;Tyzine;Tyzine hydrochloride;Visine;Visine hydrochloride;Vislin;Yxin;
EINECS(EC#)208-329-3
Molecular FormulaC₁₃H₁₆N₂^.HCl
Molecular Weight236.74

Chemical Properties

Appearanceoff-white solid
storage tempRefrigerator

Safety Data

Hazard Xi:Irritant;
Risk R22;R36/37/38
Safety

Poison by ingestion, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by an unspecified route: sleep changes, dyspnea and body temperature decrease. When heated to decomposition it emits very toxic fumes of HCl and NO_x.
Safety information of Visine (CAS NO.522-48-5):
Hazard Codes Harmful Xn, Irritant Xi
Risk Statements
R22 Harmful if swallowed
R36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 Wear suitable protective clothing
WGK Germany: 3
RTECS: NJ4550000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - domestic	LD50	intramuscular	150mg/kg (150mg/kg)		Compilation of LD50 Values of New Drugs.
child	TDLo	oral	175mg/kg (175mg/kg)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION ENDOCRINE: HYPOGLYCEMIA	Clinical Pediatrics Vol. 35, Pg. 539, 1996.
infant	TDLo	unreported	80mg/kg (80mg/kg)	BEHAVIORAL: SLEEP LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Spokane County Medical Society Bulletin. Vol. 29, Pg. 17, 1955.
mouse	LD50	intraperitoneal	110mg/kg (110mg/kg)		Compilation of LD50 Values of New Drugs.
mouse	LD50	intravenous	39mg/kg (39mg/kg)		"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 113, 1969.
mouse	LD50	oral	345mg/kg (345mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.
mouse	LD50	subcutaneous	245mg/kg (245mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.
rat	LD50	intraperitoneal	122mg/kg (122mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.
rat	LD50	intravenous	35mg/kg (35mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.
rat	LD50	oral	785mg/kg (785mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.
rat	LD50	subcutaneous	500mg/kg (500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Drugs in Japan Vol. 6, Pg. 495, 1982.

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1H-Imidazole,4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1) cas no:522-48-5

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