52205-73-9|Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2)Products Supply

Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2) cas no:52205-73-9

Synonyms: Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt (9CI);Emcyt;Estramustine phosphate disodium;Estramustine phosphatedisodium salt;Ro 21-8837/001;

Identification

NameEstra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2)
CAS52205-73-9
SynonymsEstra-1,3,5(10)-triene-3,17-diol(17b)-,3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt (9CI);Emcyt;Estramustine phosphate disodium;Estramustine phosphatedisodium salt;Ro 21-8837/001;
EINECS(EC#)257-735-7
Molecular FormulaC₂₃H₃₀Cl₂NNa₂O₆P
Molecular Weight564.35

Safety Data

Safety

Poison by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na₂O, NO_x, Cl⁻, and PO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 3gm/kg (3000mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	intravenous	380mg/kg (380mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	oral	> 12gm/kg (12000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	subcutaneous	5200mg/kg (5200mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rabbit	LD50	oral	5655mg/kg (5655mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	intravenous	208mg/kg (208mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	oral	5400mg/kg (5400mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	subcutaneous	9gm/kg (9000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.

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Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2) cas no:52205-73-9

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