52205-73-9|Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2)Products Supply

Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2) cas no:52205-73-9

Synonyms: Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt (9CI);Emcyt;Estramustine phosphate disodium;Estramustine phosphatedisodium salt;Ro 21-8837/001;

Identification

NameEstra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2)
CAS52205-73-9
SynonymsEstra-1,3,5(10)-triene-3,17-diol(17b)-,3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt (9CI);Emcyt;Estramustine phosphate disodium;Estramustine phosphatedisodium salt;Ro 21-8837/001;
EINECS(EC#)257-735-7
Molecular FormulaC₂₃H₃₀Cl₂NNa₂O₆P
Molecular Weight564.35

Safety Data

Safety

Poison by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na₂O, NO_x, Cl⁻, and PO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 3gm/kg (3000mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS GASTROINTESTINAL: "HYERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	intravenous	380mg/kg (380mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	oral	> 12gm/kg (12000mg/kg)		Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
mouse	LD50	subcutaneous	5200mg/kg (5200mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rabbit	LD50	oral	5655mg/kg (5655mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	intravenous	208mg/kg (208mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	oral	5400mg/kg (5400mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: HEMATURIA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.
rat	LD50	subcutaneous	9gm/kg (9000mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 1141, 1980.

supplier list

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

IFFECT CHEMPHAR CO., LTD.: Tel:86-25-84679300; Address: 509, FuXin International Building, No.359 HongWu R

Shanghai Longschem Co.,Ltd: Tel:; Address: Shanghai Jincheng Road 338 6# 1002 Room

Coral Drugs Pvt. Limited: Tel:+91-(11)-66300100; Address: 1001, Akash Deep building, 26-A, Barakhamba Road, New Delhi 110001,

Aceto Corporation: Tel:+1-(516)-627-6000; Address: One Hallow Lane, Lake Success, New York 11042-1215,

Shanghai Richem International Co., Ltd.: Tel:+86-(21)-31263688; Address: Room 603, Golden Eagle Mansion A, No.1518 Minsheng Road, Pudong, Shanghai 200135,

Zonk Drug R&D Limited: Tel:+86-(20)-85660382; Address: 3rd, 4th, 5th floor, B Building, Shangshehenglu, Tangxia, Guangzhou,

China ShengDa Pharmaceutical Company: Tel:+86-(755)-81240788; Address: Shenzhen Tech-Innovatio,The Tenth Road,South, Shenzhen, GuangDong 518058,

Nanjing FineTech Chemical Co., Ltd.: Tel:+86-(25)-52078417; Address: No.18 Shiyang Road, Wanyuan Industrial Zone, Jiangning, Nanjing, Jiangsu 211100,

Shreeji Pharma International: Tel:+91-265-3019110; Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018,

Kouting Chemical Co.,Ltd: Tel:+86-(21)-58116473; Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318,

Acynter Laboratory: Tel:+86-18858184290; Address: Rm.21-3-301, Jialuyuan West

Anhui Chlor-Alkali Chemical Group Co.Ltd: Tel:0086-551-4529985; Address: LANG XI ROAD HEFEI ,ANHUI,P.R.CHINA

Bo Jia Science and Technology (Wuhan) Co., Ltd.: Tel:02787526690-8155; Address: Wuhan City, Hubei Province Luo Yu Road, Hongshan No. 424 Technology Innovation Center, 14 Floor, Block A

innocechem-api: Tel:18918206905; Address: shanghai

Estra-1,3,5(10)-triene-3,17-diol(17b)-,3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt(1:2) cas no:52205-73-9

Directory

supplier list