525-66-6|2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-Products Supply

2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- cas no:525-66-6

Synonyms: 2-Propanol,1-(isopropylamino)-3-(1-naphthyloxy)- (7CI,8CI); (?à)-Propranolol; 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol;3-(Naphth-1-yloxy)-1-(isopropylamino)propan-2-ol; AY 64043; Betalong;DL-Propranolol; Euprovasin; Innopran XL; Propranolol; Proprasylyt; Racemicpropranolol; Reducor; dl-Propranolol; b-Propranolol

Identification

Name2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-
CAS525-66-6
Synonyms2-Propanol,1-(isopropylamino)-3-(1-naphthyloxy)- (7CI,8CI); (?à)-Propranolol; 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol;1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol;3-(Naphth-1-yloxy)-1-(isopropylamino)propan-2-ol; AY 64043; Betalong;DL-Propranolol; Euprovasin; Innopran XL; Propranolol; Proprasylyt; Racemicpropranolol; Reducor; dl-Propranolol; b-Propranolol
EINECS(EC#)208-378-0
Molecular FormulaC16H21 N O2
Molecular Weight259.38

Chemical Properties

AppearanceWhite, odorless crystalline powder.
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Data

Hazard Highly toxic.
Safety

A deadly human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: cardiac arrhythmias, hallucinations, hypoglycemia, convulsions, and thyroid malfunction. Human reproductive and teratogenic effects by ingestion: extra embryonic structures, abnormal Apgar score in newborn, and abnormal growth statistics. Mutation data reported.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	LDLo	oral	800ug/kg/12H (0.8mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	British Medical Journal. Vol. 2, Pg. 254, 1978.
child	TDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Medical Journal of Australia. Vol. 1, Pg. 82, 1981.
dog	LDLo	intraperitoneal	40mg/kg (40mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Pharmazie. Vol. 31, Pg. 635, 1976.
dog	LDLo	oral	120mg/kg (120mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69(4), Pg. 262P, 1973.
guinea pig	LD50	intravenous	26mg/kg (26mg/kg)		Dissertationes Pharmaceuticae et Pharmacologicae. Vol. 24, Pg. 103, 1972.
human	LDLo	intravenous	71ug/kg (0.071mg/kg)		Lancet. Vol. 1, Pg. 165, 1967.
human	TDLo	oral	2300ug/kg/D (2.3mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	British Medical Journal. Vol. 1, Pg. 1182, 1978.
man	TDLo	oral	8343mg/kg/4Y- (8343mg/kg)	ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Archives of Internal Medicine. Vol. 143, Pg. 2193, 1983.
man	TDLo	unreported	22857ug/kg/40 (22.857mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR	British Medical Journal. Vol. 289, Pg. 1490, 1984.
mouse	LD50	intraperitoneal	42mg/kg (42mg/kg)	AUTONOMIC NERVOUS SYSTEM: BETA ADRENERGIC BLOCKAGE	Ain Shams Medical Journal. Vol. 30, Pg. 23, 1979.
mouse	LD50	intravenous	24400ug/kg (24.4mg/kg)		United States Patent Document. Vol. #4013663,
mouse	LD50	oral	289mg/kg (289mg/kg)	AUTONOMIC NERVOUS SYSTEM: BETA ADRENERGIC BLOCKAGE	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1831, 1980.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)		Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
rat	LD50	intravenous	23mg/kg (23mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Pharmazie. Vol. 31, Pg. 635, 1976.
rat	LD50	oral	660mg/kg (660mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Pharmazie. Vol. 31, Pg. 635, 1976.
women	LDLo	oral	120mg/kg (120mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 41, Pg. 190, 1977.
women	TDLo	oral	3200ug/kg/2D- (3.2mg/kg)	ENDOCRINE: HYPOGLYCEMIA	Israel Journal of Medical Sciences. Vol. 18, Pg. 725, 1982.
women	TDLo	oral	708mg/kg/39W- (708mg/kg)		Annals of Pharmacotherpy. Vol. 27, Pg. 512, 1993.

supplier list

AOPHARM: Tel:86-311-66600578; Address: C-2103 Wonder Business Square, 15 Yuhua West Rd.

Beijing HuameiHuli Biochem Ltd: Tel:010-86181995; Address: Beijing TongZhou District

Facus Pharmaceutical Co., Ltd.: Tel:+86-(574)-6237-8411; Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

ACIC Fine Chemicals Inc.: Tel:+1-(800)-265-6727; Address: 11772 West Sample Road, Coral Springs, Florida 33065,

Varda Biotech Pvt. Ltd.: Tel:+91-(22)-6693 5686; Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,

Weistar Industry Limited: Tel:+86-(572)-2172208, 2172216; Address: 8th Floor, Meixin Business Building, No.820 Fenghuang Road, Huzhou, Zhejiang 313000,

Sterocn Lab & Garcn International Company: Tel:+86-(531)-8231508; Address: Tianqiao Bldg,Jiluo Road, Jinan, Shandong,

ICI Pharmaceuticals: Tel:+91-(44)-26288990; Address: 546, West Extension, VI Street, (Near SBOA School), Anna Nagar (W), Chennai, Tamil Nadu 600101,

FOYO: Tel:; Address: No.433 Wuyi Road(N),Hutang town,Wujin,Chang-Zhou,JiangSu China

Bhageria Dye-Chem LTD.: Tel:+91-22-28760936, 28748394; Address: A/101, Virwani Industrial Estate,W.E. Highway, Goregaon (E)Mumbai - 400 063. India.

Changzhou Yabang Pharmaceutical Co., LTD: Tel:; Address: 6# Liangchang Donglu, Jintan, Changzhou, Jiangsu, China

SINOCHEM NINGBO LTD.: Tel:86-574-87260209 87348868; Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

AFINE CHEMICALS LIMITED: Tel:86-571-85232161; Address: 6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China

2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- cas no:525-66-6

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