L-Glutamic acid,N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- cas no:528-74-5

NameL-Glutamic acid,N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
CAS528-74-5
SynonymsGlutamicacid, N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-(6CI,7CI); Glutamic acid,N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(8CI); 3,5-Dichloromethotrexate; 3',5'-Dichloroamethopterin;3',5'-Dichloromethotrexate; Dichloromethotrexate; Methotrexate, dichloro-; NSC145883; NSC 29630
Molecular FormulaC20H20 Cl2 N8 O5
Molecular Weight523.38

refractive index1.739

Safety

Moderately toxic by intraperitoneal and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and Cl⁻.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	655mg/kg (655mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	intravenous	1021mg/kg (1021mg/kg)	behavioral: excitement behavioral: muscle weakness behavioral: ataxia	National Technical Information Service. Vol. PB82-172644,
rat	LD50	unreported	3130ug/kg (3.13mg/kg)		United States Patent Document. Vol. #4746662,