prednisone cas no:53-03-2
Synonyms: Prednisone,98%; 17-alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione
Nameprednisone
CAS53-03-2
SynonymsPrednisone,98%; 17-alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione
EINECS(EC#)200-160-3
Molecular FormulaC21H26O5
Molecular Weight358.43
AppearanceWhite crystalline powder
alpha169 o (C=0.5, DIOXANE)
refractive index170 ° (C=0.5, Dioxane)
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Hazard Xn:Harmful
Risk R63
Safety
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Hazard Codes:Xn,C,F
Risk Statements
R63:Possible risk of harm to the unborn child.
R34:Causes burns.
R11:Highly Flammable.
Safety Statements
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition - No smoking .
WGK Germany:3
RTECS:TU4154100
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
LDLo |
oral |
400ug/kg (0.4mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Irish Journal of Medical Science. Vol. 155, Pg. 234, 1986. |
| man |
TDLo |
oral |
857ug/kg (0.857mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE |
Neurology. Vol. 36, Pg. 729, 1986. |
| mouse |
LD50 |
intramuscular |
600mg/kg (600mg/kg) |
? |
Cancer Research. Vol. 42, Pg. 122, 1982. |
| mouse |
LD50 |
intraperitoneal |
135mg/kg (135mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| mouse |
LD50 |
subcutaneous |
101mg/kg (101mg/kg) |
? |
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| women |
TDLo |
oral |
2400ug/kg/2D- (2.4mg/kg) |
PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE |
Neurology. Vol. 36, Pg. 729, 1986. |
| women |
TDLo |
unreported |
113mg/kg (113mg/kg) |
BLOOD: HEMORRHAGE
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1260, 1980. |
