10H-Phenothiazine-10-propanamine,N,N-dimethyl-, hydrochloride (1:1) cas no:53-60-1
Synonyms: 10H-Phenothiazine-10-propanamine,N,N-dimethyl-, monohydrochloride (9CI);Phenothiazine,10-[3-(dimethylamino)propyl]-, monohydrochloride (8CI);10-(g-Dimethylamino-n-propyl)phenothiazinehydrochloride;Esparinal;Liranol;Prolactyl;Promazine hydrochloride;Promazine monohydrochloride;Promwill;Propazin;Propazin (pharmaceutical);Propazine;Sparine;Talofen;
Name10H-Phenothiazine-10-propanamine,N,N-dimethyl-, hydrochloride (1:1)
CAS53-60-1
Synonyms10H-Phenothiazine-10-propanamine,N,N-dimethyl-, monohydrochloride (9CI);Phenothiazine,10-[3-(dimethylamino)propyl]-, monohydrochloride (8CI);10-(g-Dimethylamino-n-propyl)phenothiazinehydrochloride;Esparinal;Liranol;Prolactyl;Promazine hydrochloride;Promazine monohydrochloride;Promwill;Propazin;Propazin (pharmaceutical);Propazine;Sparine;Talofen;
EINECS(EC#)200-179-7
Molecular FormulaC17H20N2S.HCl
Molecular Weight320.91
storage temp2-8°C
Hazard Xn: Harmful;
Risk R22;R43
Safety
Poison by ingestion, subcutaneous, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, tremors, antipsychotic effects. An additive permitted in food for human consumption; also permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO8575000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-,
monohydrochloride
- CAS REGISTRY NUMBER :
- 53-60-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C17-H20-N2-S.Cl-H
- MOLECULAR WEIGHT :
- 320.91
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 20 mg/kg/D-I
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - tremor
Behavioral - antipsychotic
- REFERENCE :
- JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year:
123,553,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research.
(Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way,
Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 5,269,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 356 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 54,295,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APMCB4 Annales Pharmaceutic. (Poznan, Poland) V.3-13, 1965-78.
Discontinued. Volume(issue)/page/year: 13,51,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 4400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
Volume(issue)/page/year: -,-,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,42,1972
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3224
No. of Facilities: 57 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 1876 (estimated)
No. of Female Employees: 940 (estimated)
