cat |
LD50 |
oral |
320mg/kg (320mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
cat |
LDLo |
intravenous |
20200ug/kg (20.2mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 726, 1983. |
dog |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
dog |
LD50 |
oral |
160mg/kg (160mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968. |
guinea pig |
LD |
skin |
> 100mg/kg (100mg/kg) |
BEHAVIORAL: EXCITEMENT |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986. |
guinea pig |
LD50 |
intraperitoneal |
143mg/kg (143mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
guinea pig |
LD50 |
intravenous |
180mg/kg (180mg/kg) |
? |
Journal de Pharmacologie. Vol. 2, Pg. 259, 1971. |
guinea pig |
LD50 |
oral |
100mg/kg (100mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968. |
hamster |
LD50 |
oral |
81mg/kg (81mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
human |
TDLo |
oral |
113mg/kg/8W-I (113mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: OTHER CHANGES |
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 636, 1983. |
infant |
TDLo |
intravenous |
200ug/kg (0.2mg/kg) |
BLOOD: HEMORRHAGE |
Journal of Pediatrics. Vol. 107, Pg. 312, 1985. |
infant |
TDLo |
oral |
400ug/kg/2D-I (0.4mg/kg) |
GASTROINTESTINAL: NECROTIC GHANGES |
Journal of Pediatrics. Vol. 107, Pg. 484, 1985. |
mammal (species unspecified) |
LD50 |
oral |
8mg/kg (8mg/kg) |
? |
Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985. |
man |
LDLo |
oral |
15mg/kg/2W-I (15mg/kg) |
BLOOD: APLASTIC ANEMIA |
Israel Journal of Medical Sciences. Vol. 17, Pg. 433, 1981. |
man |
TDLo |
multiple routes |
3557mg/kg/5Y- (3557mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" |
American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972. |
man |
TDLo |
oral |
714ug/kg (0.714mg/kg) |
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: ATAXIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Allergy. Vol. 54, Pg. 90, 1999. |
man |
TDLo |
oral |
4286ug/kg/2D- (4.286mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Postgraduate Medical Journal. Vol. 72, Pg. 186, 1996. |
man |
TDLo |
oral |
22500ug/kg/3W (22.5mg/kg) |
LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: OTHER CHANGES |
British Medical Journal. Vol. 3, Pg. 155, 1967. |
man |
TDLo |
oral |
22500ug/kg/3W (22.5mg/kg) |
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE |
Annals of Pharmacotherpy. Vol. 29, Pg. 883, 1994. |
man |
TDLo |
rectal |
2586mg/kg/3.5 (2586mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" |
American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972. |
man |
TDLo |
unreported |
499mg/kg/87W- (499mg/kg) |
BEHAVIORAL: STIFFNESS
KIDNEY, URETER, AND BLADDER: HEMATURIA |
Arthritis and Rheumatism. Vol. 20, Pg. 917, 1977. |
mouse |
LD50 |
intramuscular |
18200ug/kg (18.2mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
mouse |
LD50 |
intraperitoneal |
10mg/kg (10mg/kg) |
? |
Archivos de Farmacologia y Toxicologia. Vol. 8, Pg. 201, 1982. |
mouse |
LD50 |
intravenous |
30mg/kg (30mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1198, 1969. |
mouse |
LD50 |
oral |
11841ug/kg (11.841mg/kg) |
? |
German Offenlegungsschrift Patent Document. Vol. #3005827, |
mouse |
LD50 |
subcutaneous |
18300ug/kg (18.3mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
rabbit |
LD50 |
oral |
135mg/kg (135mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 90, 1982. |
rat |
LD |
skin |
> 250mg/kg (250mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986. |
rat |
LD50 |
intramuscular |
26300ug/kg (26.3mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980. |
rat |
LD50 |
intraperitoneal |
13mg/kg (13mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 38, Pg. 127, 1976. |
rat |
LD50 |
intravenous |
21mg/kg (21mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 655, 1981. |
rat |
LD50 |
oral |
2420ug/kg (2.42mg/kg) |
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH |
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1526, 1975. |
rat |
LD50 |
rectal |
31900ug/kg (31.9mg/kg) |
? |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986. |
rat |
LD50 |
subcutaneous |
12mg/kg (12mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968. |
women |
TDLo |
oral |
2098ug/kg/1D- (2.098mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Southern Medical Journal. Vol. 78, Pg. 1390, 1985. |
women |
TDLo |
oral |
10mg/kg (10mg/kg) |
BEHAVIORAL: COMA |
Japanese Journal of Toxicology. Vol. 12, Pg. 337, 1999. |