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Indomethacin cas no:53-86-1

Synonyms: indomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin; 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid

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Identification
NameIndomethacin
CAS53-86-1
Synonymsindomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin; 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid
EINECS(EC#)200-186-5
Molecular FormulaC19H16ClNO4
Molecular Weight357.79
Chemical Properties
AppearanceWhite crystalline powder
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard T+:Verytoxic;
Risk R28
Safety

A poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: aplastic anemia, changes in kidney tubules, decreased urine volume, diarrhea, fibrous hepatitis, hemorrhage, hypermotility, liver changes, necrotic stomach changes, retinal changes. Human teratogenic effects by ingestion and intravenous routes: developmental abnormalities of the respiratory system and urogenital system, homeostasis, other neonatal effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic Cl? and NOx.
Hazard Codes of Indomethacin (CAS NO.53-86-1):?T+,Xi
Risk Statements: 28-36/37/38?
R28: Very toxic if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37-45-26?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
F: 8-10
HazardClass:? 6.1
PackingGroup:? I


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 320mg/kg (320mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
cat LDLo intravenous 20200ug/kg (20.2mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 726, 1983.
dog LD50 intravenous 100mg/kg (100mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
dog LD50 oral 160mg/kg (160mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
guinea pig LD skin > 100mg/kg (100mg/kg) BEHAVIORAL: EXCITEMENT Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986.
guinea pig LD50 intraperitoneal 143mg/kg (143mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
guinea pig LD50 intravenous 180mg/kg (180mg/kg) ? Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
guinea pig LD50 oral 100mg/kg (100mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
hamster LD50 oral 81mg/kg (81mg/kg) ? Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
human TDLo oral 113mg/kg/8W-I (113mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 636, 1983.
infant TDLo intravenous 200ug/kg (0.2mg/kg) BLOOD: HEMORRHAGE Journal of Pediatrics. Vol. 107, Pg. 312, 1985.
infant TDLo oral 400ug/kg/2D-I (0.4mg/kg) GASTROINTESTINAL: NECROTIC GHANGES Journal of Pediatrics. Vol. 107, Pg. 484, 1985.
mammal (species unspecified) LD50 oral 8mg/kg (8mg/kg) ? Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985.
man LDLo oral 15mg/kg/2W-I (15mg/kg) BLOOD: APLASTIC ANEMIA Israel Journal of Medical Sciences. Vol. 17, Pg. 433, 1981.
man TDLo multiple routes 3557mg/kg/5Y- (3557mg/kg) SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972.
man TDLo oral 714ug/kg (0.714mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Allergy. Vol. 54, Pg. 90, 1999.
man TDLo oral 4286ug/kg/2D- (4.286mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Postgraduate Medical Journal. Vol. 72, Pg. 186, 1996.
man TDLo oral 22500ug/kg/3W (22.5mg/kg) LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"

LIVER: OTHER CHANGES		 British Medical Journal. Vol. 3, Pg. 155, 1967.
man TDLo oral 22500ug/kg/3W (22.5mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE Annals of Pharmacotherpy. Vol. 29, Pg. 883, 1994.
man TDLo rectal 2586mg/kg/3.5 (2586mg/kg) SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE" American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972.
man TDLo unreported 499mg/kg/87W- (499mg/kg) BEHAVIORAL: STIFFNESS

KIDNEY, URETER, AND BLADDER: HEMATURIA		 Arthritis and Rheumatism. Vol. 20, Pg. 917, 1977.
mouse LD50 intramuscular 18200ug/kg (18.2mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
mouse LD50 intraperitoneal 10mg/kg (10mg/kg) ? Archivos de Farmacologia y Toxicologia. Vol. 8, Pg. 201, 1982.
mouse LD50 intravenous 30mg/kg (30mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1198, 1969.
mouse LD50 oral 11841ug/kg (11.841mg/kg) ? German Offenlegungsschrift Patent Document. Vol. #3005827,
mouse LD50 subcutaneous 18300ug/kg (18.3mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rabbit LD50 oral 135mg/kg (135mg/kg) ? Drugs in Japan Vol. 6, Pg. 90, 1982.
rat LD skin > 250mg/kg (250mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986.
rat LD50 intramuscular 26300ug/kg (26.3mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rat LD50 intraperitoneal 13mg/kg (13mg/kg) ? Toxicology and Applied Pharmacology. Vol. 38, Pg. 127, 1976.
rat LD50 intravenous 21mg/kg (21mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 655, 1981.
rat LD50 oral 2420ug/kg (2.42mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1526, 1975.
rat LD50 rectal 31900ug/kg (31.9mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat LD50 subcutaneous 12mg/kg (12mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
women TDLo oral 2098ug/kg/1D- (2.098mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED		 Southern Medical Journal. Vol. 78, Pg. 1390, 1985.
women TDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: COMA Japanese Journal of Toxicology. Vol. 12, Pg. 337, 1999.

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