53-86-1|IndomethacinProducts Supply - Chemical intermediates Network

Indomethacin cas no:53-86-1

Synonyms: indomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin; 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid

Identification

NameIndomethacin
CAS53-86-1
Synonymsindomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin; 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid
EINECS(EC#)200-186-5
Molecular FormulaC19H16ClNO4
Molecular Weight357.79

Chemical Properties

AppearanceWhite crystalline powder
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1

Safety Data

Hazard T+:Verytoxic;
Risk R28
Safety

A poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: aplastic anemia, changes in kidney tubules, decreased urine volume, diarrhea, fibrous hepatitis, hemorrhage, hypermotility, liver changes, necrotic stomach changes, retinal changes. Human teratogenic effects by ingestion and intravenous routes: developmental abnormalities of the respiratory system and urogenital system, homeostasis, other neonatal effects. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic Cl^? and NO_x.
Hazard Codes of Indomethacin (CAS NO.53-86-1):?T+,Xi
Risk Statements: 28-36/37/38?
R28: Very toxic if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 28-36/37-45-26?
S28: After contact with skin, wash immediately with plenty of soap-suds.?
S36/37: Wear suitable protective clothing and gloves.?
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
F: 8-10
HazardClass:? 6.1
PackingGroup:? I

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	oral	320mg/kg (320mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
cat	LDLo	intravenous	20200ug/kg (20.2mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 726, 1983.
dog	LD50	intravenous	100mg/kg (100mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
dog	LD50	oral	160mg/kg (160mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
guinea pig	LD	skin	> 100mg/kg (100mg/kg)	BEHAVIORAL: EXCITEMENT	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986.
guinea pig	LD50	intraperitoneal	143mg/kg (143mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
guinea pig	LD50	intravenous	180mg/kg (180mg/kg)	?	Journal de Pharmacologie. Vol. 2, Pg. 259, 1971.
guinea pig	LD50	oral	100mg/kg (100mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
hamster	LD50	oral	81mg/kg (81mg/kg)	?	Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
human	TDLo	oral	113mg/kg/8W-I (113mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 636, 1983.
infant	TDLo	intravenous	200ug/kg (0.2mg/kg)	BLOOD: HEMORRHAGE	Journal of Pediatrics. Vol. 107, Pg. 312, 1985.
infant	TDLo	oral	400ug/kg/2D-I (0.4mg/kg)	GASTROINTESTINAL: NECROTIC GHANGES	Journal of Pediatrics. Vol. 107, Pg. 484, 1985.
mammal (species unspecified)	LD50	oral	8mg/kg (8mg/kg)	?	Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985.
man	LDLo	oral	15mg/kg/2W-I (15mg/kg)	BLOOD: APLASTIC ANEMIA	Israel Journal of Medical Sciences. Vol. 17, Pg. 433, 1981.
man	TDLo	multiple routes	3557mg/kg/5Y- (3557mg/kg)	SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE"	American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972.
man	TDLo	oral	714ug/kg (0.714mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Allergy. Vol. 54, Pg. 90, 1999.
man	TDLo	oral	4286ug/kg/2D- (4.286mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Postgraduate Medical Journal. Vol. 72, Pg. 186, 1996.
man	TDLo	oral	22500ug/kg/3W (22.5mg/kg)	LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)" LIVER: OTHER CHANGES	British Medical Journal. Vol. 3, Pg. 155, 1967.
man	TDLo	oral	22500ug/kg/3W (22.5mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM LARGE INTESTINE	Annals of Pharmacotherpy. Vol. 29, Pg. 883, 1994.
man	TDLo	rectal	2586mg/kg/3.5 (2586mg/kg)	SENSE ORGANS AND SPECIAL SENSES: "RETINAL CHANGES (PIGMENTARY DEPOSITIONS, RETINITIS, OTHER): EYE"	American Journal of Ophthalmology. Vol. 73, Pg. 846, 1972.
man	TDLo	unreported	499mg/kg/87W- (499mg/kg)	BEHAVIORAL: STIFFNESS KIDNEY, URETER, AND BLADDER: HEMATURIA	Arthritis and Rheumatism. Vol. 20, Pg. 917, 1977.
mouse	LD50	intramuscular	18200ug/kg (18.2mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)	?	Archivos de Farmacologia y Toxicologia. Vol. 8, Pg. 201, 1982.
mouse	LD50	intravenous	30mg/kg (30mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1198, 1969.
mouse	LD50	oral	11841ug/kg (11.841mg/kg)	?	German Offenlegungsschrift Patent Document. Vol. #3005827,
mouse	LD50	subcutaneous	18300ug/kg (18.3mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rabbit	LD50	oral	135mg/kg (135mg/kg)	?	Drugs in Japan Vol. 6, Pg. 90, 1982.
rat	LD	skin	> 250mg/kg (250mg/kg)	?	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 3185, 1986.
rat	LD50	intramuscular	26300ug/kg (26.3mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1398, 1980.
rat	LD50	intraperitoneal	13mg/kg (13mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 38, Pg. 127, 1976.
rat	LD50	intravenous	21mg/kg (21mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 655, 1981.
rat	LD50	oral	2420ug/kg (2.42mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 1526, 1975.
rat	LD50	rectal	31900ug/kg (31.9mg/kg)	?	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 2259, 1986.
rat	LD50	subcutaneous	12mg/kg (12mg/kg)	?	Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
women	TDLo	oral	2098ug/kg/1D- (2.098mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Southern Medical Journal. Vol. 78, Pg. 1390, 1985.
women	TDLo	oral	10mg/kg (10mg/kg)	BEHAVIORAL: COMA	Japanese Journal of Toxicology. Vol. 12, Pg. 337, 1999.

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Indomethacin cas no:53-86-1

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