Phenylalanine,4-[bis(2-chloroethyl)amino]- cas no:531-76-0

NamePhenylalanine,4-[bis(2-chloroethyl)amino]-
CAS531-76-0
SynonymsAlanine,3-[p-[bis(2-chloroethyl)amino]phenyl]-, DL- (8CI); DL-Phenylalanine,4-[bis(2-chloroethyl)amino]-; DL-Phenylalanine mustard; DL-Sarcolysin;DL-Sarcolysine; Merphalan
Molecular FormulaC13H18 Cl2 N2 O2
Molecular Weight305.23

Safety

Suspected carcinogen with experimental tumorigenic data. A poison by ingestion, intraperitoneal, intravenous, and intracerebral routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits very toxic fumes of Cl⁻ and NO_x.

1.		mmo-omi 10 mmol/L		MUREAV    Mutation Research. 23 (1974),5.
2.		pic-omi 5 mmol/L		MUREAV    Mutation Research. 1 (1964),355.
3.		orl-rat LD50:105 mg/kg		AICCA6    Acta Unio Internationalis Contra Cancrum. 20 (1964),144.
4.		ipr-rat LD50:18 mg/kg		DKBSAS    Doklady Biological Sciences (English Translation). 171 (1966),801.
5.		ivn-rat LD50:25 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 8 (1958),340.
6.		ice-rat LD50:250 µg/kg		JPPMAB    Journal of Pharmacy and Pharmacology. 18 (1966),760.
7.		orl-mus LD50:35 mg/kg		XPHPAW    U.S. Public Health Service Publication. 441 (1974),165.
8.		ipr-mus LD50:26 mg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 16 (1966),634.