6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride (1:1) cas no:53152-21-9

Name6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride (1:1)
CAS53152-21-9
Synonyms6,14-Ethenomorphinan-7-methanol,17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride, (aS,5a,7a)- (9CI); 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-, hydrochloride, [5a,7a(S)]-; Buprederm; Buprenex; Buprenorphinehydrochloride; CL 112302; Lepetan; M 6029; MR 56; NIH 8805; UM 952; Vetergesic
EINECS(EC#)258-396-8
Molecular FormulaC29H41 N O4 . Cl H
Molecular Weight504.17

storage temp-0°C

Hazard Xn
Risk 22
Safety

Hazard Codes of Buprenorphine hydrochloride (CAS NO.53152-21-9): Xn
Risk Statements: 22 
R22: Harmful if swallowed.
WGK Germany: 3
RTECS: KM7758000
Poison by intravenous route. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	79mg/kg (79mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984.
mammal (species unspecified)	LD50	intravenous	40mg/kg (40mg/kg)		Yakkyoku. Pharmacy. Vol. 35, Pg. 1351, 1984.
man	TDLo	oral	2857ug/kg (2.857mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT	British Medical Journal. Vol. 296, Pg. 214, 1988.
mouse	LD50	intramuscular	> 600mg/kg (600mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: ATAXIA BLOOD: CHANGES IN SPLEEN	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse	LD50	intravenous	72mg/kg (72mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse	LD50	oral	800mg/kg (800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LIVER: OTHER CHANGES	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
mouse	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat	LD50	intramuscular	> 600mg/kg (600mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) BLOOD: CHANGES IN SPLEEN BEHAVIORAL: ATAXIA	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat	LD50	intravenous	62mg/kg (62mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat	LD50	oral	> 1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: CHANGES IN SPLEEN	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 486, 1982.