2H-1,3,5-Thiadiazine-2-thione,tetrahydro-3,5-dimethyl- cas no:533-74-4
Synonyms: 2-Thio-3,5-dimethyltetrahydro-1,3,5-thiadiazine;3,5-Dimethyl-2-thionotetrahydro-1,3,5-thiadiazine;3,5-Dimethyltetrahydro-1,3,5-thiadiazine-2-thione;Basamid P;Basamid-Puder;Busan 1058;Crag 974;D 35;DMTT;Dimethylformocarbothialdine;Fennosan B 100;Metasol D 3TA;Mylone;Mylone 85;N 521;Nalcon 243;Nefusan;Stauffer N 521;Tetrahydro-3,5-dimethyl-2H-1,3,5-thiodiazin-2-thione;Thiazon;Thiazone;UCC974;
Name2H-1,3,5-Thiadiazine-2-thione,tetrahydro-3,5-dimethyl-
CAS533-74-4
Synonyms2-Thio-3,5-dimethyltetrahydro-1,3,5-thiadiazine;3,5-Dimethyl-2-thionotetrahydro-1,3,5-thiadiazine;3,5-Dimethyltetrahydro-1,3,5-thiadiazine-2-thione;Basamid P;Basamid-Puder;Busan 1058;Crag 974;D 35;DMTT;Dimethylformocarbothialdine;Fennosan B 100;Metasol D 3TA;Mylone;Mylone 85;N 521;Nalcon 243;Nefusan;Stauffer N 521;Tetrahydro-3,5-dimethyl-2H-1,3,5-thiodiazin-2-thione;Thiazon;Thiazone;UCC974;
EINECS(EC#)208-576-7
Molecular FormulaC5H10N2S2
Molecular Weight162.27
Appearancewhite to yellow powder
refractive index1.655
storage temp0-6°C
Hazard Toxic by ingestion and inhalation.
Risk R22
Safety Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact and subcutaneous routes. A severe eye irritant. A mild primary skin irritant and sensitizer. When heated to decomposition it emits very toxic fumes of NOx and SOx.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI2800000
- CHEMICAL NAME :
- 2H-1,3,5-Thiadiazine-2-thione,
tetrahydro-3,5-dimethyl-
- CAS REGISTRY NUMBER :
- 533-74-4
- BEILSTEIN REFERENCE NO. :
- 0116039
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C5-H10-N2-S2
- MOLECULAR WEIGHT :
- 162.29
- WISWESSER LINE NOTATION :
- T6NYS ENTJ A1 BUS E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1103,1986
** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8400 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport
Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year:
9,225,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2260 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 17,S327,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 87 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 17,S327,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 17,S327,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 17,S327,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 248 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of
Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
Japan) V.1- 1976- Volume(issue)/page/year: 17,S327,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 650 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,430,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Vascular - BP elevation not characterized in autonomic section
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 127 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3120 mg/kg/30D-C
- TOXIC EFFECTS :
- Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in bladder weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22119 mg/kg/2Y-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Liver - changes in liver weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,521,1966
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 2 mg/m3 JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 26940
No. of Facilities: 203 (estimated)
No. of Industries: 5
No. of Occupations: 10
No. of Employees: 1206 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 26940
No. of Facilities: 1320 (estimated)
No. of Industries: 9
No. of Occupations: 11
No. of Employees: 25682 (estimated)
No. of Female Employees: 528 (estimated)
