Guanidine,N-(4-ethoxyphenyl)-N',N''-bis(4-methoxyphenyl)-, hydrochloride (1:1) cas no:537-05-3

NameGuanidine,N-(4-ethoxyphenyl)-N',N''-bis(4-methoxyphenyl)-, hydrochloride (1:1)
CAS537-05-3
SynonymsGuanidine,2-(p-ethoxyphenyl)-1,3-bis(p-methoxyphenyl)-, monohydrochloride (8CI);Guanidine, N-(4-ethoxyphenyl)-N',N''-bis(4-methoxyphenyl)-, monohydrochloride(9CI); Acoin; Acoin oil; Acoine; Guanicaine;N,N'-Bis[4-methoxyphenyl]-N''-(4-ethoxyphenyl)guanidine hydrochloride;Phenodianisyl; a,g-Di-p-anisyl-b-p-phenethylguanidinehydrochloride
Molecular FormulaC23H25 N3 O3 . Cl H
Molecular Weight427.97

Safety

Poison by ingestion, intravenous, and subcutaneous routes. Solutions are decomposed by light. When Phenodianisyl hydrochloride (CAS NO.537-05-3) is heated to decomposition, it emits very toxic fumes of HCl and NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	75mg/kg (75mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1291, 1935.
guinea pig	LDLo	subcutaneous	150mg/kg (150mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1291, 1935.
mouse	LDLo	intravenous	53mg/kg (53mg/kg)	BEHAVIORAL: GENERAL ANESTHETIC	"Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936Vol. -, Pg. -, 1936.
mouse	LDLo	subcutaneous	300mg/kg (300mg/kg)	BEHAVIORAL: EXCITEMENT	"Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933Vol. -, Pg. -, 1933.
rabbit	LDLo	subcutaneous	150mg/kg (150mg/kg)		Merck Index. Vol. 10, Pg. 1043, 1983.