4H-Dibenzo[de,g]quinoline,9-[4,5-dimethoxy-2-[[(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-,(6aS)- cas no:5373-42-2

Synonyms: 4H-Dibenzo[de,g]quinoline,9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-,[S-(R*,R*)]-; 6aa-Aporphine,9-[[4,5-dimethoxy-a-((S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2,10-trimethoxy-(8CI); Thalicarpine (7CI); (+)-Thalicarpine; NSC 68075; Taliblastine;Thaliblastine; Thalicarpin

Identification

Name4H-Dibenzo[de,g]quinoline,9-[4,5-dimethoxy-2-[[(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-,(6aS)-
CAS5373-42-2
Synonyms4H-Dibenzo[de,g]quinoline,9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-,[S-(R*,R*)]-; 6aa-Aporphine,9-[[4,5-dimethoxy-a-((S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2,10-trimethoxy-(8CI); Thalicarpine (7CI); (+)-Thalicarpine; NSC 68075; Taliblastine;Thaliblastine; Thalicarpin
Molecular FormulaC41H48 N2 O8
Molecular Weight696.91

Chemical Properties

refractive index1.589

Safety Data

Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

1.	dni-rat:leu 20 mg/L	MUREAV Mutation Research. 147 (1985),303.
2.	dnd-mam:lym 125 µg/L	JPMSAE Journal of Pharmaceutical Sciences. 63 (1974),474.
3.	orl-rat LD50:1500 mg/kg	DBANAD Doklady Bolgarskoi Akademii Nauk. 28 (1975),709.
4.	ipr-rat LD50:140 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) JAN 86 .
5.	ivn-rat LD50:78,300 µg/kg	DBANAD Doklady Bolgarskoi Akademii Nauk. 28 (1975),709.
6.	orl-mus LD50:1542 mg/kg	NCIAL* Progress Report Submitted to the National Cancer Institute by Arthur D. Little, Inc. (Cambridge, MA.: )1969,60.
7.	ipr-mus LD50:247 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 17 (1970),284.
8.	ivn-mus LD50:43,700 µg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB82-166299 .
9.	ivn-mky LDLo:42 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 22 (1972),304.

supplier list

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road, Shirley, NY 11967, USA