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Ribostamycin sulfate cas no:53797-35-6

Synonyms: Streptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;Vistamycin (TN);Ribomycine;5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;SF 733 antibioic sulfate;Ribostamin;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulfate;Ribostamycin sulfate salt;Prestwick_190;Ribostamycin sulfate (JP14);Ribostamycin sulphate;Riboflavine sulfate;Landamycine;GA4+7;

Identification
NameRibostamycin sulfate
CAS53797-35-6
SynonymsStreptamine, O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1-4)-O-(beta-D-ribofuranosyl-(1-5))-2-deoxy-, sulfate;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;Vistamycin (TN);Ribomycine;5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[(2S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol; sulfuric acid;SF 733 antibioic sulfate;Ribostamin;(2R,3R,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol sulfate;Ribostamycin sulfate salt;Prestwick_190;Ribostamycin sulfate (JP14);Ribostamycin sulphate;Riboflavine sulfate;Landamycine;GA4+7;
EINECS(EC#)258-783-1
Molecular FormulaC17H34N4O10.H2SO4
Molecular Weight552.55
Chemical Properties
AppearanceCOA
storage temp2-8°C
Safety Data

Hazard T,Xi
Risk R61
Safety

Poison by intravenous route. Moderately toxic by intraperitoneal, intramuscular, and subcutaneous routes. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx and SOx.
 

Hazard Codes: T,Xi
Risk Statements:
20:  Harmful by inhalation
21:  Harmful in contact with skin
22:  Harmful if swallowed 
36:  Irritating to the eyes
38:  Irritating to the skin
61:  May cause harm to the unborn child 
Safety Statements:
22:  Do not breathe dust
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 1561mg/kg (1561mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 intraperitoneal 1981mg/kg (1981mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
mouse LD50 intravenous 210mg/kg (210mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 oral > 7gm/kg (7000mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
mouse LD50 subcutaneous 2345mg/kg (2345mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat LD50 intramuscular 2030mg/kg (2030mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
rat LD50 intraperitoneal 3080mg/kg (3080mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
rat LD50 intravenous 375mg/kg (375mg/kg)   Japan Medical Gazette. Vol. 10(2), Pg. 5, 1973.
rat LD50 oral > 7gm/kg (7000mg/kg)   Drugs in Japan Vol. 6, Pg. 885, 1982.
rat LD50 subcutaneous 5600mg/kg (5600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.

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