54-62-6|AminopterinumProducts Supply - Chemical intermediates Network

Aminopterinum cas no:54-62-6

Synonyms: Aminopterine; Aminopterin; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; 4-Aminofolic Acid; 4-amino-4-deoxypteroylglutamate; 4-amino-folicaci; 4-aminofolicacid[qr]; 4-amino-pga[qr]; 4-aminopteroylglutamicacid[qr]; 4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci; AGPA; ai3-26079[qr]

Identification

NameAminopterinum
CAS54-62-6
SynonymsAminopterine; Aminopterin; N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid; 4-Aminofolic Acid; 4-amino-4-deoxypteroylglutamate; 4-amino-folicaci; 4-aminofolicacid[qr]; 4-amino-pga[qr]; 4-aminopteroylglutamicacid[qr]; 4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci; AGPA; ai3-26079[qr]
EINECS(EC#)200-209-9
Molecular FormulaC19H20N8O5
Molecular Weight440.41

Chemical Properties

AppearanceYellow solid.
alpha18 º (C=1% IN 0.1N NAOH)
refractive index1.761
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(a)

Safety Data

Hazard T+:Verytoxic;
Risk R61;R28
Safety

Poison by ingestion and intraperitoneal routes. Human and experimental teratogenic data. Other experimental reproductive effects. Mutation data reported. Human systemic effects by ingestion: gastrointestinal. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NO_x.

Hazard Codes: T+
Risk Statements:
26: Very Toxic by inhalation
27: Very Toxic in contact with skin
28: Very Toxic if swallowed
61: May cause harm to the unborn child
63: Possible risk of harm to the unborn child
Safety Statements:
22: Do not breathe dust
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53: Avoid exposure - obtain special instruction before use

Toxicity

1.	spm-mus-ipr 2 mg/kg/5D	PNASA6 Proceedings of the National Academy of Sciences of the United States of America. 78 (1978),4425.
2.	mnt-mus-ipr 5 mg/kg/5D-C	CNJGA8 Canadian Journal of Genetics and Cytology. 21 (1979),319.
3.	orl-wmn TDLo:120 µg/kg:GIT	AJOGAH American Journal of Obstetrics and Gynecology. 63 (1952),1298.
4.	orl-rat LDLo:2500 µg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 95 (1949),303.
5.	ipr-rat LD50:3 mg/kg	CANCAR Cancer. 9 (1956),955.
6.	orl-mus LD50:3 mg/kg	CKFRAY Ceskoslovenska Farmacie. 28 (1979),159.
7.	ipr-mus LD50:1900 µg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 95 (1949),303.

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Aminopterinum cas no:54-62-6

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