dog |
LDLo |
intravenous |
100mg/kg (100mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933. |
guinea pig |
LDLo |
intraperitoneal |
500mg/kg (500mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: EXCITEMENT |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933. |
guinea pig |
LDLo |
oral |
600mg/kg (600mg/kg) |
|
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940. |
guinea pig |
LDLo |
subcutaneous |
500mg/kg (500mg/kg) |
|
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940. |
mouse |
LD50 |
intraperitoneal |
500mg/kg (500mg/kg) |
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Japanese Journal of Pharmacology. Vol. 3, Pg. 99, 1954. |
mouse |
LD50 |
intravenous |
484mg/kg (484mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940. |
mouse |
LD50 |
oral |
362mg/kg (362mg/kg) |
|
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. |
mouse |
LDLo |
subcutaneous |
400mg/kg (400mg/kg) |
|
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940. |
rabbit |
LDLo |
intravenous |
100mg/kg (100mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933. |
rabbit |
LDLo |
oral |
750mg/kg (750mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933. |
rabbit |
LDLo |
subcutaneous |
200mg/kg (200mg/kg) |
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: FOOD INTAKE (ANIMAL) |
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 152, Pg. 250, 1930. |
rat |
LD50 |
intraperitoneal |
540mg/kg (540mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT |
Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 416, 1949. |
rat |
LD50 |
intratracheal |
232mg/kg (232mg/kg) |
|
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982. |
rat |
LD50 |
oral |
764mg/kg (764mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940. |