Vincaleukoblastine,4'-deoxy-3',4'-epoxy-22-oxo-, (3'a,4'a)- cas no:54022-49-0
Synonyms: 1H-Indolizino[8,1-cd]carbazole,vincaleukoblastine deriv.; 2H-3,13-Methanooxireno[9,10]azacycloundecino[5,4-b]indole,vincaleukoblastine deriv.; 22-Oxoleurosine; F-Leurosine; Formylleurosine;Leuroformine; N-Demethyl-N-formylleurosine; N-Formyl N-demethylleurosine;N-Formylleurosine; NSC 269419; Vinformide
NameVincaleukoblastine,4'-deoxy-3',4'-epoxy-22-oxo-, (3'a,4'a)-
CAS54022-49-0
Synonyms1H-Indolizino[8,1-cd]carbazole,vincaleukoblastine deriv.; 2H-3,13-Methanooxireno[9,10]azacycloundecino[5,4-b]indole,vincaleukoblastine deriv.; 22-Oxoleurosine; F-Leurosine; Formylleurosine;Leuroformine; N-Demethyl-N-formylleurosine; N-Formyl N-demethylleurosine;N-Formylleurosine; NSC 269419; Vinformide
Molecular FormulaC46H54 N4 O10
Molecular Weight0
refractive index1.684
storage tempHygroscopic, -20°C Freezer, Under Inert Atmosphere
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LR2962000
- CHEMICAL NAME :
- Formyl-leurosine
- CAS REGISTRY NUMBER :
- 54022-49-0
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C46-H54-N4-O10
- MOLECULAR WEIGHT :
- 823.04
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
19,1113,1983
