2,4,6,8-Nonatetraenoicacid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester,(2E,4E,6E,8E)- cas no:54350-48-0
Synonyms: 2,4,6,8-Nonatetraenoicacid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester, (all-E)-;Ethylall-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate;Ethyl etrinoate;Etretinate;Ro 10-9359;Tegison;Tigason;Tigasone;
Name2,4,6,8-Nonatetraenoicacid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester,(2E,4E,6E,8E)-
CAS54350-48-0
Synonyms2,4,6,8-Nonatetraenoicacid, 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-, ethyl ester, (all-E)-;Ethylall-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate;Ethyl etrinoate;Etretinate;Ro 10-9359;Tegison;Tigason;Tigasone;
EINECS(EC#)259-119-3
Molecular FormulaC23H30O3
Molecular Weight354.49
AppearanceCrystalline solid
refractive index1.544
storage tempAmber Vial, -20°C Freezer
Safety
Human systemic effects: dermatitis, nail and hair changes, increased body temperature. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| human |
TDLo |
oral |
78mg/kg/26W-I (78mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
SKIN AND APPENDAGES (SKIN): NAILS: OTHER |
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 842, 1982. |
| man |
TDLo |
oral |
1136mg/kg/9Y- (1136mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE |
Lancet. Vol. 1, Pg. 235, 1988. |
| mouse |
LD50 |
intraperitoneal |
1gm/kg (1000mg/kg) |
|
United States Patent Document. Vol. #4105681, |
| mouse |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
|
Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982. |
| mouse |
LD50 |
subcutaneous |
> 1gm/kg (1000mg/kg) |
|
Drugs in Japan Vol. -, Pg. 191, 1990. |
| rabbit |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
|
Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982. |
| rat |
LD50 |
intraperitoneal |
> 1gm/kg (1000mg/kg) |
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 5033, 1982. |
| rat |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 5033, 1982. |
| rat |
LD50 |
subcutaneous |
> 1gm/kg (1000mg/kg) |
|
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 5033, 1982. |
| women |
TDLo |
oral |
80ug/kg/8D-I (0.08mg/kg) |
LIVER: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
British Journal of Dermatology. Vol. 112, Pg. 373, 1985. |
| women |
TDLo |
oral |
60mg/kg/17W-I (60mg/kg) |
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
CUTIS; Cutaneous Medicine for the Practitioner. Vol. 35, Pg. 466, 1985. |
