D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- cas no:54749-90-5

NameD-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
CAS54749-90-5
SynonymsCHLZ;Chlorozotocin; Chlorozotocine; DCNU; NCI 178248; NSC 178248
Molecular FormulaC9H16 Cl N3 O7
Molecular Weight313.73

refractive index1.664

Hazardclass6.1(b)

Safety

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When Chlorozotocin (CAS NO.54749-90-5) is heated to decomposition, it emits very toxic fumes of Cl⁻ and NO_x. See also NITROSAMINES.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	oral	3mg/kg (3mg/kg)	GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"	Toxicology. Vol. 12, Pg. 31, 1979.
human	TDLo	intravenous	2027ug/kg/5D (2.027mg/kg)	BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Cancer Treatment Reports. Vol. 63, Pg. 17, 1979.
man	TDLo	intravenous	500mg/kg (500mg/kg)	BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: THROMBOCYTOPENIA	Cancer Vol. 46, Pg. 2365, 1980.
monkey	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology. Vol. 12, Pg. 31, 1979.
mouse	LD50	intraperitoneal	35mg/kg (35mg/kg)		INSERM Symposium. Vol. 19, Pg. 123, 1981.
mouse	LD50	intravenous	24900ug/kg (24.9mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: CHANGES IN SPLEEN	Toxicology. Vol. 12, Pg. 31, 1979.
mouse	LD50	subcutaneous	66230ug/kg (66.23mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
rat	LD50	intraperitoneal	28mg/kg (28mg/kg)	LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA GASTROINTESTINAL: OTHER CHANGES	Cancer Letters Vol. 8, Pg. 133, 1979.
rat	LD50	intravenous	22500ug/kg (22.5mg/kg)	LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Oncology. Vol. 37, Pg. 177, 1980.
rat	LDLo	subcutaneous	40mg/kg (40mg/kg)		Toxicology and Applied Pharmacology. Vol. 82, Pg. 540, 1986.