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Amitriptylinehydrochloride cas no:549-18-8

Synonyms: Amitriptyline hydrochloride; amitriptyline hcl methanol solution; AMITRYPTILLINE HCL; Amitriptyline HCl

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Identification
NameAmitriptylinehydrochloride
CAS549-18-8
SynonymsAmitriptyline hydrochloride; amitriptyline hcl methanol solution; AMITRYPTILLINE HCL; Amitriptyline HCl
EINECS(EC#)208-964-6
Molecular FormulaC20H23N?HCl
Molecular Weight313.86426
Chemical Properties
Appearancewhite to off-white powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T:Toxic
Risk R23/24/25;R36/37/38;R42/43;R63
Safety

Hazard Codes:?ToxicT,FlammableF
Risk Statements: 23/24/25-36/37/38-42/43-63-39/23/24/25-11?
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R42/43:May cause sensitization by inhalation and skin contact.?
R63:Possible risk of harm to the unborn child.?
R39:Danger of very serious irreversible effects.?
R11:Highly flammable.
Safety Statements: 22-26-36/37/39-45-36/37-16?
S22:Do not breathe dust.?
S16:Keep away from sources of ignition.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HO9450000
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: convulsions, respiratory depression, changes in sleep, hallucinations, muscle contractions, somnolence, blood pressure decrease, coma, cyanosis, dyspnea, and ataxia. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of HCl and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 37mg/kg (37mg/kg) ? Drug Development Research. Vol. 22, Pg. 385, 1991.
child LDLo oral 62500ug/kg (62.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 New England Journal of Medicine. Vol. 267, Pg. 1031, 1962.
child LDLo oral 62500ug/kg (62.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 American Journal of Diseases of Children. Vol. 106, Pg. 501, 1963.
child TDLo oral 4167ug/kg (4.167mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"		 New England Journal of Medicine. Vol. 267, Pg. 1031, 1962.
child TDLo oral 58mg/kg (58mg/kg) BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Southern Medical Journal. Vol. 82, Pg. 1588, 1989.
dog LD50 intramuscular > 23mg/kg (23mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 899, 1972.
dog LD50 intravenous > 27mg/kg (27mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 899, 1972.
dog LDLo oral 200mg/kg (200mg/kg) ? Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 889, 1972.
guinea pig LDLo intravenous 52mg/kg (52mg/kg) CARDIAC: OTHER CHANGES Therapie. Vol. 20, Pg. 67, 1965.
human TDLo oral 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: COMA		 JAMA, Journal of the American Medical Association. Vol. 230, Pg. 1405, 1974.
man TDLo oral 714ug/kg/1D-I (0.714mg/kg) BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS		 Human Psychopharmacology. Vol. 7, Pg. 273, 1992.
man TDLo oral 14286ug/kg (14.286mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Lancet. Vol. 2, Pg. 543, 1963.
man TDLo oral 60mg/kg/3W-I (60mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: WITHDRAWAL		 Journal of Clinical Psychiatry. Vol. 53, Pg. 160, 1992.
monkey LDLo intravenous 20300ug/kg (20.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Indian Journal of Experimental Biology. Vol. 22, Pg. 539, 1984.
mouse LD50 intraperitoneal 65mg/kg (65mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Journal of Drug Research. Vol. 16, Pg. 7, 1985.
mouse LD50 intravenous 21mg/kg (21mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 808, 1971.
mouse LD50 oral 140mg/kg (140mg/kg) ? Wiener Medizinische Wochenschrift. Vol. 111, Pg. 256, 1961.
mouse LD50 subcutaneous 80mg/kg (80mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 889, 1972.
rabbit LD50 intravenous 9900ug/kg (9.9mg/kg) ? "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 61, 1972.
rat LD50 intraperitoneal 67mg/kg (67mg/kg) ? Drugs in Japan Vol. -, Pg. 49, 1990.
rat LD50 intravenous 14mg/kg (14mg/kg) ? "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 61, 1972.
rat LD50 oral 240mg/kg (240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 889, 1972.
rat LD50 subcutaneous 385mg/kg (385mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 European Journal of Pharmacology. Vol. 32, Pg. 108, 1975.
women LDLo oral 19mg/kg (19mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA		 Lancet. Vol. 2, Pg. 543, 1963.
women TDLo oral 10mg/kg (10mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Canadian Medical Association Journal. Vol. 129, Pg. 1203, 1983.

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