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Tamoxifen citrate cas no:54965-24-1

Synonyms: Farmifeno;Oncomox;Tamoxifen citrate (JAN/USP);Tafoxen;Kessar;Tamoxasta;Tamoxifenum [INN-Latin];Nolvadex (TN);Soltamox;Noxitem;Oncotam;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Crisafeno;Nourytan;Tamoplex;Tamofen;ICI 46474;Tamax;Tamoxifene [INN-French];Tamoxen;Nolvadex;Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl-,2-hydroxy- 1,2,3-propanetricarboxylate (1:1);2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-ethanamine; 2-hydroxypropane-1,2,3-tricarboxylic acid;Valodex;Ethanamine, 2-[4- (1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propane-tricarboxylate (1:1);

Identification
NameTamoxifen citrate
CAS54965-24-1
SynonymsFarmifeno;Oncomox;Tamoxifen citrate (JAN/USP);Tafoxen;Kessar;Tamoxasta;Tamoxifenum [INN-Latin];Nolvadex (TN);Soltamox;Noxitem;Oncotam;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Crisafeno;Nourytan;Tamoplex;Tamofen;ICI 46474;Tamax;Tamoxifene [INN-French];Tamoxen;Nolvadex;Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl-,2-hydroxy- 1,2,3-propanetricarboxylate (1:1);2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-ethanamine; 2-hydroxypropane-1,2,3-tricarboxylic acid;Valodex;Ethanamine, 2-[4- (1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propane-tricarboxylate (1:1);
EINECS(EC#)259-415-2
Molecular FormulaC26H29NO.C6H8O7
Molecular Weight563.64
Chemical Properties
Appearancewhite to off-white powder
storage temp2-8°C
Safety Data

Hazard T:Toxic
Risk R22;R45
Safety

Confirmed human carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human systemic effects: visual field changes, retinal changes. An anti-estrogenic drug. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:?ToxicT,IrritantXi
Risk Statements: 45-60-61-22-64-36/37/38?
R45:May cause cancer.?
R60:May impair fertility.?
R61:May cause harm to the unborn child.?
R22:Harmful if swallowed.?
R64:May cause harm to breastfed babies.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 53-36/37/39-45-36-26?
S53:Avoid exposure - obtain special instructions before use.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: KH2387000


Toxicity
1. ???

add-rat-ipr 60?mg/kg/3D-C

??? CNREA8 ?? Cancer Research. 52 (1992),1360.
2. ???

add-ham-ipr 10?mg/kg

??? CNREA8 ?? Cancer Research. 52 (1992),1360.
3. ???

orl-rat TDLo:15,512?mg/kg/1Y-I:CAR

??? CRNGDP ?? Carcinogenesis. 14 (1993),315.
4. ???

orl-wmn TDLo:154?mg/kg/1Y-I:EYE

??? AJOPAA ?? American Journal of Ophthalmology. 104 (1987),185.
5. ???

orl-rat LD50:1190?mg/kg

??? JZKEDZ ?? Jitchuken, Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Preclinical Reports. 6 (1980),1.
6. ???

ipr-rat LD50:575?mg/kg

??? JZKEDZ ?? Jitchuken, Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Preclinical Reports. 6 (1980),1.
7. ???

orl-mus LD50:3100?mg/kg

??? JRPFA4 ?? Journal of Reproduction and Fertility. 13 (1967),101.
8. ???

ipr-mus LD50:218?mg/kg

??? NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),440.

?Tamoxifen citrate (CAS NO.54965-24-1) has been listed as a carcinogen by? IARC: Group 1 carcinogen .It may cause neurotoxic effects. See actual entry in RTECS for complete information. The toxicological properties have not been fully investigated.

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YiPeng Chemical
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Intatrade Chemicals GmbH
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Kangrui BIO-TECH Co.,Ltd.(H.K.)
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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
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Wuhan Senwayer Century chemical Co.,Ltd
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Hangzhou Dayangchem Co., Ltd.
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Zhejiang Haiqiang Chemical Co.,Ltd.
Tel:86-571-86960370
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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
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Address: daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China
Finetech Industry limited.
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Address: chukang Road, Wuhan, Hubei 430073,
Muscle Building Nutrition Inc.
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Address: 35 Dongchang East Road, Liaocheng City, Shandong
Zhejiang Kaili Industrial Co., Ltd.
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Shanghai UCHEM Inc.
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Boc Sciences
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Address: 45-16 Ramsey Road Shirley, NY 11967, USA

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