Ethanamine,N-ethyl-N-nitroso- cas no:55-18-5

NameEthanamine,N-ethyl-N-nitroso-
CAS55-18-5
SynonymsDiethylamine,N-nitroso- (6CI,8CI); DEN; DEN (mutagen); DENA; Diethylnitrosamide;Diethylnitrosamine; Diethylnitrosoamine; N,N-Diethylnitrosoamine;N-Ethyl-N-nitrosoethanamine; N-Nitroso-N,N-diethylamine; N-Nitrosodiethylamine;NDEA; NSC 132; Nitrosodiethylamine
EINECS(EC#)200-226-1
Molecular FormulaC4H10 N2 O
Molecular Weight102.16

Appearanceyellow liquid
refractive indexn20/D 1.437
storage temp2-8°C

Hazardclass6.1(b)

Hazard T,F
Risk 45-22-39/23/24/25-23/24/25-11
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NO_x. See also N-NITROSO COMPOUNDS and AMINES.
Hazard Codes of N-Nitrosodiethylamine (CAS NO.55-18-5): T,F
Risk Statements: 45-22-39/23/24/25-23/24/25-11 
R11:Highly flammable. 
R22:Harmful if swallowed. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed. 
R39:Danger of very serious irreversible effects. 
R45:May cause cancer.
Safety Statements: 53-45-36/37-16 
S16:Keep away from sources of ignition. 
S36/37:Wear suitable protective clothing and gloves. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S53:Avoid exposure - obtain special instructions before use.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	intraperitoneal	175mg/kg (175mg/kg)		Carcinogenesis Vol. 5, Pg. 533, 1984.
guinea pig	LD50	oral	250mg/kg (250mg/kg)		Zeitschrift fuer Krebsforschung. Vol. 69, Pg. 103, 1967.
hamster	LD50	subcutaneous	232mg/kg (232mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: OTHER CHANGES LIVER: OTHER CHANGES	British Journal of Cancer. Vol. 33, Pg. 411, 1976.
hamster	LD50	unreported	246mg/kg (246mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LIVER: OTHER CHANGES KIDNEY, URETER, AND BLADDER: "INFLAMMATION, NECROSIS, OR SCARRING OF BLADDER"	Journal of the National Cancer Institute. Vol. 49, Pg. 595, 1972.
mouse	LD50	intramuscular	356mg/kg (356mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse	LD50	intraperitoneal	132mg/kg (132mg/kg)		JNCI, Journal of the National Cancer Institute. Vol. 62, Pg. 911, 1979.
mouse	LD50	intravenous	293mg/kg (293mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 17(10), Pg. 51, 1973.
mouse	LD50	oral	200mg/kg (200mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	National Technical Information Service. Vol. OTS0555387,
mouse	LD50	unreported	210mg/kg (210mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.
rat	LD50	intraperitoneal	216mg/kg (216mg/kg)		Biochemical Journal. Vol. 85, Pg. 72, 1962.
rat	LD50	intravenous	280mg/kg (280mg/kg)		IARC Scientific Publications. Vol. 4, Pg. 45, 1973.
rat	LD50	oral	220mg/kg (220mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: FATTY LIVER DEGERATION	Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1167, 1964.
rat	LD50	subcutaneous	195mg/kg (195mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE LIVER: OTHER CHANGES	Experimental Pathology Vol. 27, Pg. 171, 1985.
rat	LD50	unreported	245mg/kg (245mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(8), Pg. 11, 1980.