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L-Epinephrine hydrochloride cas no:55-31-2

Synonyms: 1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (9CI);1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride, (R)-;Benzyl alcohol,3,4-dihydroxy-a-[(methylamino)methyl]-,hydrochloride, (-)- (8CI);(-)-Adrenaline hydrochloride;(-)-Epinephrinehydrochloride;Adrenalin chloride;Adrenalin hydrochloride;Adrenalinechlorhydrate;Adrenaline chloride;Adrenaline hydrochloride;Epinephrinechloride;Epinephrine hydrochloride;Gelatin-Epinephrine;Glaucon;SupranephrinSolution;Suprarenin hydrochloride;Tonogen;l-Adrenaline chloride;l-Adrenalinehydrochloride;l-Epinephrine chloride;l-Methylaminoethanolcatechol hydrochloride;

Identification
NameL-Epinephrine hydrochloride
CAS55-31-2
Synonyms1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (9CI);1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride, (R)-;Benzyl alcohol,3,4-dihydroxy-a-[(methylamino)methyl]-,hydrochloride, (-)- (8CI);(-)-Adrenaline hydrochloride;(-)-Epinephrinehydrochloride;Adrenalin chloride;Adrenalin hydrochloride;Adrenalinechlorhydrate;Adrenaline chloride;Adrenaline hydrochloride;Epinephrinechloride;Epinephrine hydrochloride;Gelatin-Epinephrine;Glaucon;SupranephrinSolution;Suprarenin hydrochloride;Tonogen;l-Adrenaline chloride;l-Adrenalinehydrochloride;l-Epinephrine chloride;l-Methylaminoethanolcatechol hydrochloride;
EINECS(EC#)200-230-3
Molecular FormulaC9H14ClNO3
Molecular Weight219.67
Chemical Properties
Appearancecrystals
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Safety

Poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also VASOTONIN and other adrenalin compounds.
Safety Information aboout L-Epinephrine hydrochloride (CAS NO.55-31-2):
RIDADR: 3249
HazardClass: 6.1(a)
PackingGroup: II


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 200ug/kg (0.2mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
guinea pig LDLo subcutaneous 2mg/kg (2mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
mouse LD50 intraperitoneal 4664ug/kg (4.664mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 110, 1947.
mouse LD50 intravenous 140ug/kg (0.14mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.
mouse LD50 subcutaneous 1980ug/kg (1.98mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 214, 1946.
mouse LDLo oral 50mg/kg (50mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 51, 1963.
rat LD50 intraduodenal 35mg/kg (35mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LD50 oral 24mg/kg (24mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LD50 subcutaneous 5mg/kg (5mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969.
rat LDLo intravenous 50ug/kg (0.05mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.

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