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Atropine sulfate cas no:55-48-1

Synonyms: Atropen;Atropisol;1-.alpha.-H,5-.alpha.-H-Tropan-3-.alpha.-ol (.+-.)-tropate (ester), sulfate (2:1) salt;Atropinsal;Benzeneacetic acid,R-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3- yl ester,compounds,sulfate (2:1) (salt);1.alpha.H, 5.alpha.H-Tropan-3.alpha.-ol (.+-.)-tropate (ester), sulfate (2:1) (salt);Eyesule;Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, sulfate (2:1) (salt);Sulfate datropine [French];component of Enuretrol;Tropintran;component of Antrocol;Benzeneacetic acid, .alpha.- (hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(.+-.)-, sulfate (2:1) (salt);Atropette;Sulfatropinol;Ichtho-bellol;Atropine sulfate (VAN);Ryuato;component of Motofen;component of Isopto Atropine;1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester), sulfate (2:1) (salt) (8CI);Atropin siran;Atropine sulfate anhydrous;

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Identification
NameAtropine sulfate
CAS55-48-1
SynonymsAtropen;Atropisol;1-.alpha.-H,5-.alpha.-H-Tropan-3-.alpha.-ol (.+-.)-tropate (ester), sulfate (2:1) salt;Atropinsal;Benzeneacetic acid,R-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3- yl ester,compounds,sulfate (2:1) (salt);1.alpha.H, 5.alpha.H-Tropan-3.alpha.-ol (.+-.)-tropate (ester), sulfate (2:1) (salt);Eyesule;Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, sulfate (2:1) (salt);Sulfate datropine [French];component of Enuretrol;Tropintran;component of Antrocol;Benzeneacetic acid, .alpha.- (hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(.+-.)-, sulfate (2:1) (salt);Atropette;Sulfatropinol;Ichtho-bellol;Atropine sulfate (VAN);Ryuato;component of Motofen;component of Isopto Atropine;1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester), sulfate (2:1) (salt) (8CI);Atropin siran;Atropine sulfate anhydrous;
EINECS(EC#)200-235-0
Molecular Formula2(C17H23NO3).H2SO4
Molecular Weight676.82
Chemical Properties
AppearanceWhite crystalline powder
storage temp0-6°C
Safety Data

Hazard T+: Very toxic;
Risk R26/28
Safety

Hazard Codes:?T+
Risk Statements: 26/28?
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 23-45?
S23:Do not breathe vapour.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 2
F: 3-8-10


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LDLo oral 226mg/kg (226mg/kg) ? Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
bird - wild LDLo subcutaneous 200mg/kg (200mg/kg) ? Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
cat LD50 intravenous 36mg/kg (36mg/kg) ? Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
cat LDLo subcutaneous 30mg/kg (30mg/kg) ? "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
chicken LDLo subcutaneous 750mg/kg (750mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
child TDLo oral 20ug/kg (0.02mg/kg) BEHAVIORAL: EXCITEMENT

CARDIAC: CHANGE IN RATE

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED		 Archives of Disease in Childhood. Vol. 54, Pg. 222, 1979.
?
dog LD50 intravenous 60mg/kg (60mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
?
dog LDLo intraperitoneal 175mg/kg (175mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
dog LDLo subcutaneous 200mg/kg (200mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
duck LDLo subcutaneous 250mg/kg (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
frog LDLo subcutaneous 1200mg/kg (1200mg/kg) ? "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig LD50 subcutaneous 480mg/kg (480mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 137, Pg. 375, 1962.
?
guinea pig LDLo intraarterial 90mg/kg (90mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intraperitoneal 400mg/kg (400mg/kg) ? Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
guinea pig LDLo intravenous 70mg/kg (70mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
human TDLo intramuscular 28ug/kg (0.028mg/kg) BEHAVIORAL: ATAXIA

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Journal of Applied Physiology. Vol. 8, Pg. 635, 1956.
?
man LDLo oral 357mg/kg (357mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

GASTROINTESTINAL: OTHER CHANGES		 Hochudoku. Vol. 10, Pg. 184, 1992.
man TDLo intravenous 28ug/kg/11H-I (0.028mg/kg) ? American Journal of Diseases of Children. Vol. 137, Pg. 291, 1983.
?
man TDLo unreported 14285ng/kg (0.014285mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

BEHAVIORAL: HEADACHE

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"		 Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 273, 1991.
?
monkey LDLo subcutaneous 150mg/kg (150mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg) ? Journal of the American Chemical Society. Vol. 79, Pg. 4451, 1957.
mouse LD50 intravenous 31mg/kg (31mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 637, 1966.
?
mouse LD50 oral 468mg/kg (468mg/kg) AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 156, Pg. 467, 1965.
?
mouse LD50 subcutaneous 400mg/kg (400mg/kg) ? Therapie. Vol. 12, Pg. 412, 1957.
?
pigeon LDLo subcutaneous 210mg/kg (210mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING		 Biochemische Zeitschrift. Vol. 66, Pg. 389, 1914.
rabbit LD50 intramuscular 414mg/kg (414mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Canadian Medical Association Journal. Vol. 85, Pg. 1241, 1961.
?
rabbit LD50 intraperitoneal 200mg/kg (200mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
?
rabbit LD50 intravenous 70mg/kg (70mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC Toxicology and Applied Pharmacology. Vol. 10, Pg. 424, 1967.
?
rabbit LDLo intracrebral 1mg/kg (1mg/kg) ? Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 81, Pg. 193, 1917.
rabbit LDLo subcutaneous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.
rat LD50 intraperitoneal 215mg/kg (215mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 11, Pg. 511, 1967.
?
rat LD50 intravenous 37mg/kg (37mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 11, Pg. 511, 1967.
?
rat LD50 oral 600mg/kg (600mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 393, 1965.
?
rat LD50 subcutaneous 540mg/kg (540mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 393, 1965.
?
women TDLo multiple routes 44ug/kg/1D-I (0.044mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)		 Archives of Internal Medicine. Vol. 146, Pg. 45, 1986.
?
women TDLo ocular 20ug/kg/4H-I (0.02mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Archives of Internal Medicine. Vol. 146, Pg. 45, 1986.
?

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