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mechlorethamine hydrochloride cas no:55-86-7

Synonyms: chlormethine hydrochloride; Chloromethine Hydrochloride; nitrogen mustard hydrochloride; N-methyl-bis(2-chloroethyl)amine hydrochloride;

Identification
Namemechlorethamine hydrochloride
CAS55-86-7
Synonymschlormethine hydrochloride; Chloromethine Hydrochloride; nitrogen mustard hydrochloride; N-methyl-bis(2-chloroethyl)amine hydrochloride;
EINECS(EC#)200-246-0
Molecular FormulaC5H11Cl2N?HCl
Molecular Weight192.51
Chemical Properties
Appearancewhite crystalline powder
refractive index1.4689 (24 C)
storage temp?20°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety Data

Hazard T+:Verytoxic;
Risk R45;R46;R28;R34;R42/43
Safety

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Deadly poison by ingestion, intravenous, subcutaneous, intraperitoneal, and parenteral routes. Experimental teratogenic and reproductive effects. Human systemic effects by intravenous route: nausea or vomiting, reduction in the number of white blood cells and blood platelets. Other experimental reproductive effects. Human mutation data reported.
Safety Information of Bis(2-chloroethyl)methylaminehydrochloride (CAS NO.55-86-7):

Hazard Codes:  T+
Risk Statements:  45-46-28-34-42/43 
R45:May cause cancer. 
R46:May cause heritable genetic damage. 
R28:Very toxic if swallowed. 
R34:Causes burns. 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements:  53-36/37/39-45 
S53:Avoid exposure - obtain special instructions before use. |
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR:  UN 2811 6.1/PG 2
WGK Germany:  3
HazardClass:  6.1(a)
PackingGroup:  II


Toxicity
1.    

sln-dmg-orl 5 mmol/L

    MUREAV    Mutation Research. 95 (1982),237.
2.    

dni-hmn:hla 1 µmol/L

    MUREAV    Mutation Research. 92 (1982),427.
3.    

msc-mus:lym 20 µg/L

    FCTOD7    Food and Chemical Toxicology. 23 (1985),115.
4.    

ivn-hmn TDLo:400 µg/kg:CNS,BLD

    CLPTAT    Clinical Pharmacology and Therapeutics. 6 (1965),50.
5.    

orl-rat LD50:10 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224.
6.    

scu-rat LD50:1900 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224.
7.    

ivn-rat LD50:1100 µg/kg

    MEIEDD    Merck Index. 10 (1983),822.
8.    

par-rat LD50:1700 µg/kg

    RRCRBU    Recent Results in Cancer Research. 52 (1975),76.
9.    

orl-mus LD50:20 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224.
10.    

ipr-mus LD50:2900 µg/kg

    NYKZAU    Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 62 (1966),96.
 

 

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