Busulfan cas no:55-98-1

NameBusulfan
CAS55-98-1
SynonymsMyleran; Busulfex; Busulphan; Tetramethylene bis(methanesulfonate); 1,4-Dimethanesulfonoxybutane; 1,4-Butanediol dimethanesulfonate; 3,6-Endoxohexahydrophthalic Anhydride
EINECS(EC#)200-250-2
Molecular FormulaC6H14O6S2
Molecular Weight246.29

AppearanceWhite Crystalline Solid
storage tempHygroscopic, Refrigerator, Under Inert Atmosphere

Hazardclass6.1(b)

Hazard T:Toxic
Risk R23/24/25;R36/37/38;R45;R46;R63
Safety

Confirmed carcinogen producing leukemia, kidney, and uterine tumors. Experimental neoplastigenic and tumorigenic data. Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and possibly other routes. Ingestion by pregnant women can cause cancer of the reproductive system of the fetus including the uterus. Human teratogenic effects by ingestion and possibly other routes include developmental abnormalities of the eye, ear, craniofacial area including the nose and tongue, gastrointestinal system, endocrine system, urogenital system, and other unspecified areas. Other human reproductive effects by ingestion and possibly other routes include: impotence, changes in the uterus, cervix, and vagina, and menstrual-cycle disorders. Experimental reproductive effects. Human systemic effects by ingestion: general arteriolar or venous dilation of the eye, changes in structure or function of salivary glands. When heated to decomposition it emits toxic fumes of SO_x. See also Hazard SULFONATES.
Codes: T+,T
Risk Statements:
23: ?Toxic by inhalation
24: ?Toxic in contact with skin
25: ?Toxic if swallowed
26: ?Very Toxic by inhalation
27: ?Very Toxic in contact with skin
28: ?Very Toxic if swallowed
36: ?Irritating to the eyes
37: ?Irritating to the respiratory system
38: ?Irritating to the skin
45: ?May cause cancer
46: ?May cause heritable genetic damage
63: ?Possible risk of harm to the unborn child
Safety Statements:
28: ?After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)?
36: ?Wear suitable protective clothing?
37: ?Wear suitable gloves
39: ?Wear eye/face protection
45: ?In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
63: ?In case of accident by inhalation, remove casualty to fresh air and keep at rest
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: EK1750000
HazardClass: 6.1(b)
PackingGroup: III

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	56200ug/kg (56.2mg/kg)	?	Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
dog	LDLo	intravenous	8mg/kg (8mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS BLOOD: OTHER CHANGES	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
man	TDLo	oral	8mg/kg/2D-I (8mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 2, Pg. 1463, 1984.
monkey	LDLo	intravenous	8mg/kg (8mg/kg)	BLOOD: LEUKOPENIA BLOOD: OTHER CHANGES BLOOD: AGRANULOCYTOSIS	Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
mouse	LD50	intraperitoneal	86mg/kg (86mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1894, 1971.
mouse	LD50	oral	110mg/kg (110mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1894, 1971.
mouse	LD50	subcutaneous	63mg/kg (63mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1894, 1971.
mouse	LD50	unreported	46mg/kg (46mg/kg)	?	British Journal of Cancer. Vol. 6, Pg. 160, 1952.
rat	LD50	intraperitoneal	18mg/kg (18mg/kg)	GASTROINTESTINAL: OTHER CHANGES BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Biochemical Pharmacology. Vol. 1, Pg. 39, 1958.
rat	LD50	intravenous	1800ug/kg (1.8mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat	LD50	subcutaneous	22mg/kg (22mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 1894, 1971.
rat	LD50	unreported	10mg/kg (10mg/kg)	?	Chemical Abstracts. Vol. 55, Pg. 10679a, 1961.
rat	LDLo	oral	15mg/kg (15mg/kg)	?	Khimiya i Meditsina. Vol. 13, Pg. 34, 1960.
women	TDLo	oral	80mg/kg/8Y (80mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	JAMA, Journal of the American Medical Association. Vol. 238, Pg. 1951, 1977. ?