Aclatonium napadisilate cas no:55077-30-0
Synonyms: (2-Acetyllactoyloxyethyl)trimethylammonium 1,5-naphthalenedisulfonate;Aclatonium napadisilate [BAN:INN:JAN];Abovis;TM 723;Aciatonium napadisilat;2-(2-(Acetyloxy)-1-oxopropoxy)-N,N,N-trimethylethanaminium, 1,5-naphthalenedisulfonate (2:1);Acetyllactoylcholine 1,5-naphthalenedisulfonate;Aclatonium napadisilate (JAN);Bis(2-acetoxypropionic acid trimethylammoniumethyl ester)naphthalene-1,5-disulfonate;Aclatonio [Spanish];Bis(O-acetyllactylcholin) 1,5-naphthalindisulfonat;Ethanaminium,2-[2-(acetyloxy)-1- oxopropoxy]-N,N,N-trimethyl-,1,5- naphthalenedisulfonate (2:1);(2-Acetyllactoyloxyethyl)trimethylammonium hemi-1,5-naphthalenedisulfonate;SKF 100916-J;Bis(O-acetyllactoylcholin) 1,5-naphthalindisulfonat;Abovis (TN);Napadisilate daclatonium [INN-French];2-(2-(Acetyloxy)-1-oxopropoxy)-N,N,N-trimethylethanaminium 1,5-naphthalenedisulfonate (2:1);Ethanaminium, 2-(2-(acetyloxy)-1-oxopropoxy)-N,N,N-trimethyl-, 1,5-naphthalenedisulfonate (2:1);Aclatonium napadisilat;Choline 1,5-naphthalenedisulfonate (2:1), dilactate, diacetate;2-(2-acetyloxypropanoyloxy)ethyl-[2-[2-(2-acetyloxypropanoyloxy)ethyl-dimethyl-ammonio]ethyl]-dimethyl-azanium; naphthalene-1,5-disulfonate;Napadisilato de aclatonio [INN-Spanish];Aclatonii napadisilas [INN-Latin];Aclatonium Napadisilate(CAS No: 55077-30-0);ABOVIS;Aciatonium napadisylate;
NameAclatonium napadisilate
CAS55077-30-0
Synonyms(2-Acetyllactoyloxyethyl)trimethylammonium 1,5-naphthalenedisulfonate;Aclatonium napadisilate [BAN:INN:JAN];Abovis;TM 723;Aciatonium napadisilat;2-(2-(Acetyloxy)-1-oxopropoxy)-N,N,N-trimethylethanaminium, 1,5-naphthalenedisulfonate (2:1);Acetyllactoylcholine 1,5-naphthalenedisulfonate;Aclatonium napadisilate (JAN);Bis(2-acetoxypropionic acid trimethylammoniumethyl ester)naphthalene-1,5-disulfonate;Aclatonio [Spanish];Bis(O-acetyllactylcholin) 1,5-naphthalindisulfonat;Ethanaminium,2-[2-(acetyloxy)-1- oxopropoxy]-N,N,N-trimethyl-,1,5- naphthalenedisulfonate (2:1);(2-Acetyllactoyloxyethyl)trimethylammonium hemi-1,5-naphthalenedisulfonate;SKF 100916-J;Bis(O-acetyllactoylcholin) 1,5-naphthalindisulfonat;Abovis (TN);Napadisilate daclatonium [INN-French];2-(2-(Acetyloxy)-1-oxopropoxy)-N,N,N-trimethylethanaminium 1,5-naphthalenedisulfonate (2:1);Ethanaminium, 2-(2-(acetyloxy)-1-oxopropoxy)-N,N,N-trimethyl-, 1,5-naphthalenedisulfonate (2:1);Aclatonium napadisilat;Choline 1,5-naphthalenedisulfonate (2:1), dilactate, diacetate;2-(2-acetyloxypropanoyloxy)ethyl-[2-[2-(2-acetyloxypropanoyloxy)ethyl-dimethyl-ammonio]ethyl]-dimethyl-azanium; naphthalene-1,5-disulfonate;Napadisilato de aclatonio [INN-Spanish];Aclatonii napadisilas [INN-Latin];Aclatonium Napadisilate(CAS No: 55077-30-0);ABOVIS;Aciatonium napadisylate;
Molecular FormulaC30H44N2O14S2
Molecular Weight722.8212
AppearanceWhite crystalline powder
Safety
Poison by intravenous route. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx. A cholinergic agent. See also SULFONATES.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
oral |
> 10gm/kg (10000mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2171, 1981. |
| mouse |
LD |
intraperitoneal |
> 400mg/kg (400mg/kg) |
? |
Yakugaku Zasshi. Journal of Pharmacy. Vol. 99, Pg. 1245, 1979. |
| mouse |
LD50 |
intravenous |
41900ug/kg (41.9mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981. |
| mouse |
LD50 |
oral |
15gm/kg (15000mg/kg) |
? |
United States Patent Document. Vol. #3903137, |
| mouse |
LD50 |
subcutaneous |
826mg/kg (826mg/kg) |
BEHAVIORAL: TREMOR
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 497, 1977. |
| rat |
LD50 |
intravenous |
46mg/kg (46mg/kg) |
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 497, 1977. |
| rat |
LD50 |
oral |
> 13889mg/kg (13889mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981. |
| rat |
LD50 |
subcutaneous |
986mg/kg (986mg/kg) |
BEHAVIORAL: TREMOR
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 497, 1977. |
