Acitretin
cas no:55079-83-9
Synonyms: 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; Neotigason; Soriatane; acitretin
NameAcitretin
CAS55079-83-9
Synonyms9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; Neotigason; Soriatane; acitretin
EINECS(EC#)259-474-4
Molecular FormulaC21H26O3
Molecular Weight326.43
Appearancecrystalline solid
refractive index1.569
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass9
Hazard T:Toxic
Risk R36/38;R61;R50/53
Safety
Hazard Codes:?
T,?
N
Risk Statements: 61-36/38-50/53?
R61:May cause harm to the unborn child.?
R36/38:Irritating to eyes and skin.?
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 53-26-45-60-61-37/39?
S53:Avoid exposure - obtain special instructions before use.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S60:This material and its container must be disposed of as hazardous waste.?
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.?
S37/39:Wear suitable gloves and eye/face protection.
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: RA8460000
F: 8-10-21
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
700mg/kg (700mg/kg) |
? |
United States Patent Document. Vol. #4105681, |
| rat |
LD50 |
oral |
> 4gm/kg (4000mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 10, Pg. 5033, 1982. |
