D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI) cas no:551-74-6

NameD-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)
CAS551-74-6
SynonymsMannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride, D- (8CI);1,6-Bis(chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride; 1,6-Bis(b-chlorethylamino)-1,6-didesoxy-D-mannitoldihydrochloride; 1,6-Bis[(2-chloroethyl)amino]-1,6-dideoxy-D-mannitoldihydrochloride; Degranol; Degranol chinoin; Dimesylmannitol hydrochloride;Mannitol mustard dihydrochloride; Mannomustine dihydrochloride; Mannomustinehydrochloride; NSC 9698
Molecular FormulaC10H22 Cl2 N2 O4 . 2 Cl H
Molecular Weight378.13

Safety

Poison by intravenous, subcutaneous, and parenteral routes. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A drug used for the treatment of malignant neoplasms. When heated to decomposition, Mannomustine dihydrochloride (CAS NO.551-74-6) emits very toxic fumes of HCl and NO_x. See also MANNOMUSTINE.

1.		cyt-hmn:lym 10 µmol/L		IPPABX    Iugoslavica Physiologica et Pharmacologica Acta. 17 (1981),131.
2.		sce-hmn:lym 3 µmol/L		IPPABX    Iugoslavica Physiologica et Pharmacologica Acta. 17 (1981),131.
3.		dnd-mus-ipr 200 mg/kg		FOBLAN    Folia Biologica (Prague). 25 (1979),380.
4.		hma-mus/esc 1 mg/kg		MUREAV    Mutation Research. 21 (1973),190.
5.		ipr-mus TDLo:23 mg/kg/4W:CAR		JNCIAM    Journal of the National Cancer Institute. 36 (1966),915.
6.		ipr-mus TDLo:7265 µg/kg/4W-I:NEO		JNCIAM    Journal of the National Cancer Institute. 36 (1966),915.
7.		par-rat LD50:56 mg/kg		RRCRBU    Recent Results in Cancer Research. 52 (1975),76.
8.		scu-mus LD50:120 mg/kg		RFECAC    Revue Francaise dEtudes Cliniques et Biologiques. 7 (1962),296.
9.		ivn-dog LDLo:7600 µg/kg		CCSUBJ    Cancer Chemotherapy Reports, Part 2. 2 (1965),201.
10.		ivn-mky LDLo:15 mg/kg		CCSUBJ    Cancer Chemotherapy Reports, Part 2. 2 (1965),201.