| man |
LDLo |
oral |
336mg/kg/47D- (336mg/kg) |
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
BLOOD: AGRANULOCYTOSIS
BLOOD: THROMBOCYTOPENIA |
Annals of Pharmacotherpy. Vol. 28, Pg. 1236, 1994. |
| man |
TDLo |
oral |
350mg/kg/7W-I (350mg/kg) |
BLOOD: AGRANULOCYTOSIS |
Postgraduate Medical Journal. Vol. 74, Pg. 126, 1998. |
| man |
TDLo |
oral |
429mg/kg/6OD- (429mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Lancet. Vol. 1, Pg. 407, 1984. |
| monkey |
LD50 |
intraperitoneal |
500mg/kg (500mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| monkey |
LD50 |
oral |
> 6gm/kg (6000mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| mouse |
LD50 |
intraperitoneal |
1250mg/kg (1250mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| mouse |
LD50 |
intravenous |
88mg/kg (88mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| mouse |
LD50 |
oral |
600mg/kg (600mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| rat |
LD50 |
intraperitoneal |
> 5gm/kg (5000mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| rat |
LD50 |
intravenous |
70mg/kg (70mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| rat |
LD50 |
oral |
1780mg/kg (1780mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
New Drugs Annual: Cardiovascular Drugs. Vol. 1, Pg. 295, 1983. |
| women |
TDLo |
oral |
100mg/kg/10D- (100mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
BLOOD: EOSINOPHILIA |
American Journal of Kidney Diseases. Vol. 25, Pg. 934, 1995. |
| women |
TDLo |
oral |
350mg/kg/5W-I (350mg/kg) |
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Annals of Pharmacotherpy. Vol. 33, Pg. 939, 1999. |
| women |
TDLo |
oral |
600mg/kg/60D- (600mg/kg) |
BLOOD: APLASTIC ANEMIA
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Israel Journal of Medical Sciences. Vol. 31, Pg. 444, 1995. |
