dog |
LD50 |
oral |
500mg/kg (500mg/kg) |
? |
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 436, 1972. |
human |
TDLo |
oral |
4111mg/kg (4111mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: MUSCLE WEAKNESS
GASTROINTESTINAL: OTHER CHANGES |
New England Journal of Medicine. Vol. 287, Pg. 867, 1972. |
man |
TDLo |
oral |
8mg/kg (8mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
American Journal of Psychiatry. Vol. 141, Pg. 909, 1984. |
man |
TDLo |
oral |
54mg/kg (54mg/kg) |
BEHAVIORAL: SLEEP
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" |
New Zealand Medical Journal. Vol. 97, Pg. 23, 1984. |
man |
TDLo |
oral |
1080mg/kg/13W (1080mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
Journal of Clinical Psychiatry. Vol. 47, Pg. 330, 1986. |
man |
TDLo |
oral |
25gm/kg/4Y-I (25000mg/kg) |
BEHAVIORAL: TREMOR
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE |
Journal of Clinical Psychiatry. Vol. 46, Pg. 292, 1985. |
mouse |
LD50 |
intraperitoneal |
236mg/kg (236mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: ATAXIA |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
mouse |
LD50 |
intravenous |
497mg/kg (497mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
mouse |
LD50 |
oral |
531mg/kg (531mg/kg) |
? |
Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970. |
mouse |
LD50 |
subcutaneous |
413mg/kg (413mg/kg) |
? |
Russian Pharmacology and Toxicology Vol. 33, Pg. 266, 1970. |
rat |
LD50 |
intraperitoneal |
156mg/kg (156mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
rat |
LD50 |
intravenous |
241mg/kg (241mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
rat |
LD50 |
oral |
525mg/kg (525mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
rat |
LD50 |
subcutaneous |
434mg/kg (434mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 1273, 1973. |
women |
TDLo |
oral |
120mg/kg/10D- (120mg/kg) |
BEHAVIORAL: EXCITEMENT |
Journal of Clinical Psychiatry. Vol. 48, Pg. 81, 1987. |
women |
TDLo |
oral |
612mg/kg/44D- (612mg/kg) |
BEHAVIORAL: SLEEP
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" |
American Journal of Psychiatry. Vol. 152, Pg. 956, 1995. |
women |
TDLo |
oral |
8760mg/kg/2Y- (8760mg/kg) |
ENDOCRINE: THYROID WEIGHT (GOITER)
ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION |
American Journal of Medicine. Vol. 99, Pg. 575, 1995. |
women |
TDLo |
oral |
36500mg/kg/10 (36500mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
ENDOCRINE: DIABETES INSIPIDUS (NEPHROGENIC OR CNS) |
Annales de Medecine Interne. Vol. 148, Pg. 284, 1997. |
women |
TDLo |
unreported |
556mg/kg/32D (556mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS |
JAMA, Journal of the American Medical Association. Vol. 213, Pg. 865, 1970.
? |