Dibenz[b,e]oxepin-3-aceticacid, 6,11-dihydro-11-oxo- cas no:55689-65-1

NameDibenz[b,e]oxepin-3-aceticacid, 6,11-dihydro-11-oxo-
CAS55689-65-1
Synonyms11-Oxo-6,11-dihydrodibenz[b,e]oxepin-3-aceticacid; 6,11-Dihydro-11-oxodibenz[b,e]oxepin-3-acetic acid; Oxepinac
Molecular FormulaC16H12 O4
Molecular Weight268.28

refractive index1.635

Safety

Poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 600mg/kg (600mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
mouse	LD50	intraperitoneal	596mg/kg (596mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
mouse	LD50	oral	852mg/kg (852mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
mouse	LD50	subcutaneous	645mg/kg (645mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
rabbit	LD50	oral	308mg/kg (308mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE GASTROINTESTINAL: PERITONITIS	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
rat	LD50	intraperitoneal	174mg/kg (174mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.
rat	LD50	oral	110mg/kg (110mg/kg)		Journal of Medicinal Chemistry. Vol. 19, Pg. 941, 1976.
rat	LD50	subcutaneous	113mg/kg (113mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: PERITONITIS	Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 445, 1978.