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Benzoic acid,3-(aminosulfonyl)-4-phenoxy-5-(1-pyrrolidinyl)- cas no:55837-27-9

Synonyms: Arelix;Arlix; Diumax; Eurelix; HOE 118; Piretanide; S 73-4118; Tauliz

Identification
NameBenzoic acid,3-(aminosulfonyl)-4-phenoxy-5-(1-pyrrolidinyl)-
CAS55837-27-9
SynonymsArelix;Arlix; Diumax; Eurelix; HOE 118; Piretanide; S 73-4118; Tauliz
EINECS(EC#)259-852-9
Molecular FormulaC17H18 N2 O5 S
Molecular Weight362.43
Chemical Properties
AppearancePale yellow powder.
refractive index1.64
Safety Data

Safety

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic agent. When heated to decomposition it emits very toxic fumes of SOx and NOx.


Toxicity
1.    

orl-rbt TDLo:13 mg/kg (female 6-18D post):TER

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4367.
2.    

orl-rat LD50:5601 mg/kg

    DRFUD4    Drugs of the Future. 2 (1977),393.
3.    

ipr-rat LD50:485 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
4.    

scu-rat LD50:1100 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
5.    

ivn-rat LD50:700 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
6.    

orl-mus LD50:2 g/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
7.    

ipr-mus LD50:700 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
8.    

scu-mus LD50:660 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
9.    

ivn-mus LD50:618 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.
10.    

orl-rbt LD50:960 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 14 (1980),4254.

 

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