56-75-7|chloroamphenicolProducts Supply - Chemical intermediates Network

chloroamphenicol cas no:56-75-7

Synonyms: chloramphenicol; 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide; chloromycetin

Identification

Namechloroamphenicol
CAS56-75-7
Synonymschloramphenicol; 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide; chloromycetin
EINECS(EC#)200-287-4
Molecular FormulaC11H12Cl2N2O5
Molecular Weight323.13

Chemical Properties

Appearancewhite to off-white crystalline powder
alpha19.5 o (C=6, ETOH)
refractive index20 ° (C=5, EtOH)
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Hazard T:Toxic
Risk R45
Safety

?Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unknown route: changes in plasma or blood volume, unspecified liver effects, and hemorrhaging. Experimental teratogenic and reproductive effects. Human mutation data reported. An antibiotic. When heated to decomposition it emits very toxic fumes of NO_x and Cl^?.
Hazard Codes:?T
Risk Statements: 45?
R45:May cause cancer.
Safety Statements: 53-45?
S53:Avoid exposure - obtain special instructions before use.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
WGK Germany: 3
RTECS of Chloramphenicol (CAS NO.56-75-7): AB6825000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	unreported	250mg/kg/10D (250mg/kg)	LIVER: OTHER CHANGES BLOOD: HEMORRHAGE BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Clinical Pediatrics Vol. 14, Pg. 499, 1975.
dog	LD	intramuscular	> 101mg/kg (101mg/kg)	?	Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
dog	LD	oral	> 300mg/kg (300mg/kg)	?	Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
dog	LDLo	intravenous	150mg/kg (150mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Bacteriology. Vol. 55, Pg. 425, 1948.
guinea pig	LD50	intravenous	560mg/kg (560mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954.
guinea pig	LD50	oral	500mg/kg (500mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955.
infant	LDLo	intravenous	30mg/kg/3D-I (30mg/kg)	CARDIAC: CARDIAC OUTPUT VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Pediatrics. Vol. 103, Pg. 487, 1983.
infant	LDLo	unreported	200mg/kg/4D-I (200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" BLOOD: EOSINOPHILIA	Lancet. Vol. 1, Pg. 555, 1986.
infant	TDLo	intramuscular	250mg/kg/2D (250mg/kg)	VASCULAR: CHANGE IN PLASMA OR BLOOD VALUME	New England Journal of Medicine. Vol. 262, Pg. 787, 1960.
infant	TDLo	oral	440mg/kg (440mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975.
mouse	LD50	intraperitoneal	1100mg/kg (1100mg/kg)	?	Dissertationes Pharmaceuticae. Vol. 14, Pg. 21, 1962.
mouse	LD50	intravenous	110mg/kg (110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
mouse	LD50	oral	1500mg/kg (1500mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 1, 1955.
mouse	LD50	subcutaneous	400mg/kg (400mg/kg)	?	"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 493, 1978.
rabbit	LD50	intravenous	117mg/kg (117mg/kg)	?	Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
rat	LD50	intraperitoneal	1811mg/kg (1811mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat	LD50	intravenous	171mg/kg (171mg/kg)	?	Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949.
rat	LD50	oral	2500mg/kg (2500mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955.
rat	LD50	subcutaneous	5gm/kg (5000mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966.
women	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: COMA VASCULAR: SHOCK LUNGS, THORAX, OR RESPIRATION: CYANOSIS	JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975.

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chloroamphenicol cas no:56-75-7

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