child |
TDLo |
unreported |
250mg/kg/10D (250mg/kg) |
LIVER: OTHER CHANGES
BLOOD: HEMORRHAGE
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Clinical Pediatrics Vol. 14, Pg. 499, 1975. |
dog |
LD |
intramuscular |
> 101mg/kg (101mg/kg) |
? |
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949. |
dog |
LD |
oral |
> 300mg/kg (300mg/kg) |
? |
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949. |
dog |
LDLo |
intravenous |
150mg/kg (150mg/kg) |
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Journal of Bacteriology. Vol. 55, Pg. 425, 1948. |
guinea pig |
LD50 |
intravenous |
560mg/kg (560mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 9, Pg. 21, 1954. |
guinea pig |
LD50 |
oral |
500mg/kg (500mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955. |
infant |
LDLo |
intravenous |
30mg/kg/3D-I (30mg/kg) |
CARDIAC: CARDIAC OUTPUT
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Pediatrics. Vol. 103, Pg. 487, 1983. |
infant |
LDLo |
unreported |
200mg/kg/4D-I (200mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
BLOOD: EOSINOPHILIA |
Lancet. Vol. 1, Pg. 555, 1986. |
infant |
TDLo |
intramuscular |
250mg/kg/2D (250mg/kg) |
VASCULAR: CHANGE IN PLASMA OR BLOOD VALUME |
New England Journal of Medicine. Vol. 262, Pg. 787, 1960. |
infant |
TDLo |
oral |
440mg/kg (440mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES |
JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975. |
mouse |
LD50 |
intraperitoneal |
1100mg/kg (1100mg/kg) |
? |
Dissertationes Pharmaceuticae. Vol. 14, Pg. 21, 1962. |
mouse |
LD50 |
intravenous |
110mg/kg (110mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949. |
mouse |
LD50 |
oral |
1500mg/kg (1500mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 1, 1955. |
mouse |
LD50 |
subcutaneous |
400mg/kg (400mg/kg) |
? |
"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 1, Pg. 493, 1978. |
rabbit |
LD50 |
intravenous |
117mg/kg (117mg/kg) |
? |
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949. |
rat |
LD50 |
intraperitoneal |
1811mg/kg (1811mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
rat |
LD50 |
intravenous |
171mg/kg (171mg/kg) |
? |
Journal of Clinical Investigation. Vol. 28, Pg. 943, 1949. |
rat |
LD50 |
oral |
2500mg/kg (2500mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 10, Pg. 3, 1955. |
rat |
LD50 |
subcutaneous |
5gm/kg (5000mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966. |
women |
LDLo |
oral |
400mg/kg (400mg/kg) |
BEHAVIORAL: COMA
VASCULAR: SHOCK
LUNGS, THORAX, OR RESPIRATION: CYANOSIS |
JAMA, Journal of the American Medical Association. Vol. 234, Pg. 149, 1975. |