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Histamine dihydrochloride cas no:56-92-8

Synonyms: 2-imidazol-4-ylethylamine dihydrochloride; Histamine-alpha,alpha,??d4?HCl)2; HISTAMINE DICHLORHYDRATE; histamine dihcl; 2-(1H-Imidazol-4-yl)ethylamine dihydrochloride; 2-(4-Imidazolyl)ethylamine dihydrochloride

Identification
NameHistamine dihydrochloride
CAS56-92-8
Synonyms2-imidazol-4-ylethylamine dihydrochloride; Histamine-alpha,alpha,??d4?HCl)2; HISTAMINE DICHLORHYDRATE; histamine dihcl; 2-(1H-Imidazol-4-yl)ethylamine dihydrochloride; 2-(4-Imidazolyl)ethylamine dihydrochloride
EINECS(EC#)200-298-4
Molecular FormulaC5H9N3?2HCl;C5H11Cl2N3
Molecular Weight184.07
Chemical Properties
Appearancewhite powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Hazard Xi:Irritant;
Risk R42
Safety

Poison by subcutaneous, intravenous, intraperitoneal, and parenteral routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl and NOx. See also HISTAMINE.
Hazard Codes: Xn, Xi
Risk Statements:36/37/38-42/43-42-22
22:(Harmful if swallowed)
36/37/38: (Irritating to the eyes piratory system and skin)
42/43:(May cause sensitization by inhalation and skin contact)
42:(May cause sensitization by inhalation)
Safety Statements:22-26-36/37/39-45-37-36/37
22:(Do not breathe dust)
26: (In case of contact with eyes,rinse immediately with plenty of water and seek medical advice)
36/37/39:(Wear suitable protective clothing, gloves and eye/face protection)
45:(In case of accident or if you feel unwell, seek medical advice immediately (show label where possible))
37:(Wear suitable gloves)
36/37:(Wear suitable protective clothing and gloves)
WGK Germany:2
RTECS:MS1575000
F:1-8-9
Hazard Note:Irritant


Toxicity
1.    

orl-mus LD50:2534 mg/kg

    ARTODN    Archives of Toxicology. 2 (1979),371.
2.    

ipr-mus LD50:184 mg/kg

    YKKZAJ    Yakugaku Zasshi. Journal of Pharmacy. 97 (1977),1117.
3.    

scu-mus LDLo:1300 mg/kg

    AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 166 (1932),437.
4.    

ivn-mus LD50:370 mg/kg

    ATSUDG    Archives of Toxicology, Supplement. 2 (1979),371.
5.    

ipr-rbt LDLo:200 mg/kg

    JIDIAQ    Journal of Infectious Diseases. 42 (1928),473.
6.    

ipr-gpg LD50:4602 µg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 77 (1943),54.
7.    

scu-gpg LD50:1250 µg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 8 (1966),339.
8.    

ivn-gpg LD50:294 µg/kg

    JAPMA8    Journal of the American Pharmaceutical Association, Scientific Edition. 33 (1944),80.
9.    

par-gpg LDLo:570 µg/kg

    AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 211 (1950),328.

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Yancheng Jingwei Chemicals Co., Ltd.
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