Pregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(11b,16a)- cas no:5611-51-8
Synonyms: Pregna-1,4-diene-3,20-dione,9-fluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal withacetone, 21-(3,3-dimethylbutyrate) (8CI); Butyric acid, 3,3-dimethyl-, 21-esterwith 9-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dionecyclic 16,17-acetal with acetone (8CI); Aristospan; CL 34433; Hexatrione;Lederlon; Lederspan; TATBA; Triamcinolone acetonide 21-tert-butylacetate;Triamcinolone acetonide tert-butyl acetate; Triamcinolone hexacetonide
NamePregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(11b,16a)-
CAS5611-51-8
SynonymsPregna-1,4-diene-3,20-dione,9-fluoro-11b,16a,17,21-tetrahydroxy-, cyclic 16,17-acetal withacetone, 21-(3,3-dimethylbutyrate) (8CI); Butyric acid, 3,3-dimethyl-, 21-esterwith 9-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dionecyclic 16,17-acetal with acetone (8CI); Aristospan; CL 34433; Hexatrione;Lederlon; Lederspan; TATBA; Triamcinolone acetonide 21-tert-butylacetate;Triamcinolone acetonide tert-butyl acetate; Triamcinolone hexacetonide
EINECS(EC#)227-031-4
Molecular FormulaC30H41 F O7
Molecular Weight 532.71
refractive index1.556
Safety
An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3930000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic
16,17-acetal with acetone, 21-(3,3-dimethylbutyrate)
- CAS REGISTRY NUMBER :
- 5611-51-8
- BEILSTEIN REFERENCE NO. :
- 1413888
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C30-H41-F-O7
- MOLECULAR WEIGHT :
- 532.71
- WISWESSER LINE NOTATION :
- T F5 E5 B666 GO IO RV AHTTTT&J A1 BF CQ E1
FV1OV1X1&1&1 H1 H1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 10-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
- REFERENCE :
- JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 10-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,747,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- 46IEAC "Current Research Trends in Prenatal Craniofacial Development,
Proceedings of an International Conference, 1980," Pratt, R.M., and R.L.
Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980
Volume(issue)/page/year: -,387,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - skin and skin
appendages
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JDREAF Journal of Dental Research. (International Assoc. for Dental
Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
Volume(issue)/page/year: 58(Spec Iss A),384,197
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- female 12 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1974- Volume(issue)/page/year:
13,443,1981
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5557
No. of Facilities: 17 (estimated)
No. of Industries: 1
No. of Occupations: 3
No. of Employees: 1088 (estimated)
No. of Female Employees: 744 (estimated)
