Doxylamine succinate cas no:562-10-7
Synonyms: 2-[[.alpha.-(2-Dimethylamino)ethoxy]-.alpha.-methylbenzyl]pyridine succinate;2-Dimethylaminoethoxyphenylmethyl-2-picoline succinate (1:1);butanedioic acid; N,N-dimethyl-2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethanamine;Doxylamine succinate (1:1);Unisom;Phenyl2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether succinate;(Dimethylamino)ethoxy-methyl-benzyl-pyridine succinate;Pyridine, 2-[.alpha.-[2- (dimethylamino)ethoxy]-.alpha.-methylbenzyl]-, succinate (1:1);Doxylamine hydrogen succinate;Gittalun;Hoggar N;Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-, succinate (1:1);2-Dimethylaminoethoxyphenylmethyl-2-picoline succinate;Butanedioic acid, compd. with N, N-dimethyl-2-[1-phenyl-1- (2-pyridinyl)ethoxy]ethanamine (1:1);
NameDoxylamine succinate
CAS562-10-7
Synonyms2-[[.alpha.-(2-Dimethylamino)ethoxy]-.alpha.-methylbenzyl]pyridine succinate;2-Dimethylaminoethoxyphenylmethyl-2-picoline succinate (1:1);butanedioic acid; N,N-dimethyl-2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethanamine;Doxylamine succinate (1:1);Unisom;Phenyl2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether succinate;(Dimethylamino)ethoxy-methyl-benzyl-pyridine succinate;Pyridine, 2-[.alpha.-[2- (dimethylamino)ethoxy]-.alpha.-methylbenzyl]-, succinate (1:1);Doxylamine hydrogen succinate;Gittalun;Hoggar N;Pyridine, 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-, succinate (1:1);2-Dimethylaminoethoxyphenylmethyl-2-picoline succinate;Butanedioic acid, compd. with N, N-dimethyl-2-[1-phenyl-1- (2-pyridinyl)ethoxy]ethanamine (1:1);
EINECS(EC#)209-228-7
Molecular FormulaC17H22N2O.C4H6O4
Molecular Weight388.45742
Appearancewhite to light cream powder
storage tempRefrigerator
Hazard Xn: Harmful;
Risk R22;R36/37/38
Safety
Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes of Doxylamine succinate (CAS NO.562-10-7): 
Xn
Risk Statements:
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intravenous |
62mg/kg (62mg/kg) |
|
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| mouse |
LD50 |
oral |
470mg/kg (470mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| mouse |
LD50 |
subcutaneous |
460mg/kg (460mg/kg) |
|
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| rabbit |
LD50 |
intravenous |
49mg/kg (49mg/kg) |
|
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| rabbit |
LD50 |
oral |
250mg/kg (250mg/kg) |
|
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| rat |
LD50 |
subcutaneous |
440mg/kg (440mg/kg) |
|
Journal of Laboratory and Clinical Medicine. Vol. 33, Pg. 325, 1948. |
| rat |
LDLo |
oral |
600mg/kg (600mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: FOOD INTAKE (ANIMAL) |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 37, Pg. 311, 1948. |
