Epirubicin hydrochloride cas no:56390-09-1
Synonyms: 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;4'-Epidoxorubicin hydrochloride;4'-epi-Adriamycinhydrochloride;Ellence;Epidoxorubicin hydrochloride;
NameEpirubicin hydrochloride
CAS56390-09-1
Synonyms5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S,10S)- (9CI);5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-;4'-Epidoxorubicin hydrochloride;4'-epi-Adriamycinhydrochloride;Ellence;Epidoxorubicin hydrochloride;
EINECS(EC#)260-145-2
Molecular FormulaC27H29NO11.HCl
Molecular Weight579.9802
AppearanceOrange-Red Crystalline Solid
refractive index1.709
storage tempDesiccate at +4°C
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| dog |
LD50 |
intravenous |
2250ug/kg (2.25mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| mouse |
LD50 |
intravenous |
31500ug/kg (31.5mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| mouse |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| mouse |
LD50 |
subcutaneous |
37500ug/kg (37.5mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| rat |
LD50 |
intraperitoneal |
10800ug/kg (10.8mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| rat |
LD50 |
intravenous |
17mg/kg (17mg/kg) |
? |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. |
| rat |
LD50 |
oral |
1350mg/kg (1350mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| rat |
LD50 |
subcutaneous |
17600ug/kg (17.6mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 200, 1990. |
| women |
TDLo |
intravenous |
1622mg/kg (1622mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Lancet. Vol. 2, Pg. 629, 1986. |
