56391-56-1|D-Streptamine,O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1®4)]-2-deoxy-N1-ethyl-Products Supply

D-Streptamine,O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1®4)]-2-deoxy-N1-ethyl- cas no:56391-56-1

Synonyms: 1-N-Ethylsisomicin;1-N-Ethylsisomycin; Netilmicin; Netromycin; Sch 20569

Identification

NameD-Streptamine,O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1®4)]-2-deoxy-N1-ethyl-
CAS56391-56-1
Synonyms1-N-Ethylsisomicin;1-N-Ethylsisomycin; Netilmicin; Netromycin; Sch 20569
EINECS(EC#)260-146-8
Molecular FormulaC21H41 N5 O7
Molecular Weight475.67

Chemical Properties

refractive index1.597

Safety Data

Safety

Poison by intravenous, intramuscular, and subcutaneous routes. An experimental teratogen. Human systemic effects by intravenous route: changes to kidney, ureter and bladder. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

1.	ivn-hmn TDLo:52 mg/kg/7D-C:KID	CMAJAX Canadian Medical Association Journal. 120 (1979),161.
2.	ipr-rat LD50:231 mg/kg	JJANAX Japanese Journal of Antibiotics. 35 (1982),461.
3.	scu-rat LD50:169 mg/kg	JJANAX Japanese Journal of Antibiotics. 35 (1982),461.
4.	ivn-rat LD50:25,200 µg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 31 (1981),816.
5.	ivn-mus LD50:22 mg/kg	JJANAX Japanese Journal of Antibiotics. 35 (1982),461.
6.	ims-mus LD50:63,100 µg/kg	JJANAX Japanese Journal of Antibiotics. 35 (1982),461.
7.	ims-mus LD50:63,100 µg/kg	JJANAX Japanese Journal of Antibiotics. 35 (1982),461.
8.	scu-dog LDLo:500 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 31 (1981),816.
9.	ims-dog LD50:125 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 31 (1981),816.
10.	scu-mky LDLo:75 mg/kg	JIDIAQ Journal of Infectious Diseases. 137 (1978),476.
11.

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D-Streptamine,O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1®4)]-2-deoxy-N1-ethyl- cas no:56391-56-1

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