2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aR,5S,5aR,6R,12aS)- cas no:564-25-0
Synonyms: 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(6CI,8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5a,5aa,6a,12aa)]-;4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;5-Hydroxy-a-6-deoxytetracycline;6-Deoxy-5-hydroxytetracycline;6-Deoxyoxytetracycline;Dentistar;Deoxymykoin;Dotur;Doximal;Doxinyl;Doxivetin;Doxy RW;Doxy-Gel;Doxycen;Doxycycline;GS 3065;Hydramycin;Liviatin;Medeomycin;Monodox;Oxytetracycline, 6-deoxy-;Pulmodox;Ronaxan;Tolexine;Unidox;Vibramycin;Vibramycine;Vibraveineuse;a-6-Deoxy-5-hydroxytetracycline;a-Doxycycline;
Name2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,(4S,4aR,5S,5aR,6R,12aS)-
CAS564-25-0
Synonyms2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(6CI,8CI);2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5a,5aa,6a,12aa)]-;4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;5-Hydroxy-a-6-deoxytetracycline;6-Deoxy-5-hydroxytetracycline;6-Deoxyoxytetracycline;Dentistar;Deoxymykoin;Dotur;Doximal;Doxinyl;Doxivetin;Doxy RW;Doxy-Gel;Doxycen;Doxycycline;GS 3065;Hydramycin;Liviatin;Medeomycin;Monodox;Oxytetracycline, 6-deoxy-;Pulmodox;Ronaxan;Tolexine;Unidox;Vibramycin;Vibramycine;Vibraveineuse;a-6-Deoxy-5-hydroxytetracycline;a-Doxycycline;
EINECS(EC#)209-271-1
Molecular FormulaC22H24N2O8
Molecular Weight444.44
Appearanceyellow crystal powder
refractive index1.737
storage tempstore in a tightly closed container.
Safety
Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
rganism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
dog |
LD50 |
intravenous |
> 100mg/kg (100mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 305, 1979. |
dog |
LD50 |
oral |
> 500mg/kg (500mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 305, 1979. |
mouse |
LD50 |
intraperitoneal |
410mg/kg (410mg/kg) |
? |
Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy. Vol. 17, Pg. 276, 1970. |
mouse |
LD50 |
intravenous |
241mg/kg (241mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 305, 1979. |
mouse |
LD50 |
oral |
1870mg/kg (1870mg/kg) |
? |
Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy. Vol. 17, Pg. 276, 1970. |
rat |
LD50 |
intraperitoneal |
378mg/kg (378mg/kg) |
? |
Therapie. Vol. 23, Pg. 575, 1968. |
rat |
LD50 |
intravenous |
228mg/kg (228mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 305, 1979. |
rat |
LD50 |
oral |
> 2gm/kg (2000mg/kg) |
? |
Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 305, 1979. |
women |
TDLo |
oral |
68mg/kg/24D-I (68mg/kg) |
MUSCULOSKELETAL: JOINTS |
Postgraduate Medical Journal. Vol. 67, Pg. 313, 1991. |