56420-45-2|5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-Products Supply

5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)- cas no:56420-45-2

Synonyms: 5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S-cis)-;4'-Epi-DX;4'-Epiadriamycin;4'-Epidoxorubicin;4'-epi-Adriamycin;4'-epi-Doxorubicin;Epiadriamycin;Epidoxorubicin;Farmarubicin;Farmarubicine;IMI 28;NSC 256942;Pharmarubicin;Pidorubicin;WP 697;

Identification

Name5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
CAS56420-45-2
Synonyms5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S,10S)- (9CI);5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,(8S-cis)-;4'-Epi-DX;4'-Epiadriamycin;4'-Epidoxorubicin;4'-epi-Adriamycin;4'-epi-Doxorubicin;Epiadriamycin;Epidoxorubicin;Farmarubicin;Farmarubicine;IMI 28;NSC 256942;Pharmarubicin;Pidorubicin;WP 697;
Molecular FormulaC₂₇H₂₉NO₁₁
Molecular Weight543.52

Chemical Properties

refractive index1.71

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	2mg/kg (2mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Toxicology and Applied Pharmacology. Vol. 79, Pg. 412, 1985.
mouse	LD50	intravenous	16070ug/kg (16.07mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 79, Pg. 412, 1985.
mouse	LD50	unreported	29300ug/kg (29.3mg/kg)	?	Biochemical Pharmacology. Vol. 38, Pg. 167, 1989.
rabbit	LDLo	intrapleural	400ug/kg (0.4mg/kg)	CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Pharmacology and Toxicology Vol. 62, Pg. 84, 1988.
rat	LD50	intravenous	14270ug/kg (14.27mg/kg)	?	Toxicology and Applied Pharmacology. Vol. 79, Pg. 412, 1985.

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5,12-Naphthacenedione,10-[(3-amino-2,3,6-trideoxy-a-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)- cas no:56420-45-2

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