6-Phthalazinecarboxylicacid, 3,4-dihydro-1-(hydroxymethyl)-5,7-dimethyl-4-oxo-, ethyl ester cas no:56611-65-5

Name6-Phthalazinecarboxylicacid, 3,4-dihydro-1-(hydroxymethyl)-5,7-dimethyl-4-oxo-, ethyl ester
CAS56611-65-5
SynonymsEG 626; NSC305351; Oxagrelate; Phthalazinol; Phthalazinol (phosphodiesterase inhibitor)
Molecular FormulaC14H16 N2 O4
Molecular Weight276.32

refractive index1.609

Safety

Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	780mg/kg (780mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.
mouse	LD50	oral	1850mg/kg (1850mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.
rabbit	LD50	intraperitoneal	700mg/kg (700mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.
rabbit	LD50	oral	1020mg/kg (1020mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.
rat	LD50	intraperitoneal	570mg/kg (570mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.
rat	LD50	oral	1750mg/kg (1750mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 6247, 1982.